{"id":"W2126601015","doi":"10.1002/chem.201203266","title":"Bending Rigid Molecular Rods: Formation of Oligoproline Macrocycles","year":2012,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Image stitching; Polyproline helix; Aziridine; Bent molecular geometry; Bending; Circular dichroism; Chemistry; Crystallography; Stereochemistry; Peptide; Materials science; Computer science; Biochemistry; Organic chemistry; Artificial intelligence; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000457631,0.0001460911,0.0001592475,0.00002080098,0.00007792837,0.00002973165,0.0002310318,0.00004845216,0.0001315528],"category_scores_gemma":[0.00009518809,0.0001294229,0.0002233249,0.0000723352,0.00005147169,0.00001284387,0.00009840977,0.0001461927,0.00001086508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001722666,"about_ca_system_score_gemma":0.00001279865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.067971e-7,"about_ca_topic_score_gemma":4.311545e-8,"domain_scores_codex":[0.998979,0.00007002083,0.0003761644,0.0001346328,0.0001604626,0.0002796584],"domain_scores_gemma":[0.9992442,0.000006119284,0.0002625099,0.0002139055,0.00007388619,0.0001994155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002043003,0.00006363853,0.0006481733,0.0000376973,0.00005439197,0.000007547483,0.000030854,0.00002095386,0.994406,0.000003020617,0.0004666313,0.004240669],"study_design_scores_gemma":[0.0002750724,0.00001671808,0.0002993356,0.00003913277,0.00005580489,0.0002754368,0.00007682351,0.0001097243,0.9857486,0.00001135502,0.01293921,0.0001527374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890222,0.001363682,0.004571377,0.00006045846,0.00003339578,0.00002305891,0.000009195844,0.000007106859,0.004909551],"genre_scores_gemma":[0.9977827,0.0002056117,0.001043262,0.00005238012,0.0006836999,8.950452e-7,0.00005206206,0.00002630391,0.0001531056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01247258,"threshold_uncertainty_score":0.5277715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008321830059709144,"score_gpt":0.2242884225412958,"score_spread":0.2159665924815866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}