{"id":"W2126667692","doi":"10.1128/jvi.02538-14","title":"Adenovirus E1A Targets the DREF Nuclear Factor To Regulate Virus Gene Expression, DNA Replication, and Growth","year":2014,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Manitoba","funders":"Canadian Institutes of Health Research; Pancreatic Cancer Action Network","keywords":"Biology; Viral replication; Promoter; Transactivation; Gene; Transcription factor; Gene knockdown; Gene expression; Host factor; Virus; Virology; Molecular biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007691785,0.000147197,0.0002184457,0.00009097822,0.0001507793,0.00002812336,0.0004743369,0.0001693043,0.00007632856],"category_scores_gemma":[0.0003622546,0.0001003536,0.00008420074,0.000082189,0.0001450111,0.000007864622,0.0001771984,0.0002202718,0.00002231631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001607488,"about_ca_system_score_gemma":0.00005112352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005808989,"about_ca_topic_score_gemma":0.00001252912,"domain_scores_codex":[0.9985102,0.0003350106,0.0003619907,0.0003063897,0.0002094996,0.0002769132],"domain_scores_gemma":[0.9986643,0.00004312592,0.0002490471,0.0006112634,0.0002396862,0.0001926336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001720066,0.00004197194,0.0005195262,0.000003864548,0.00005557401,0.000003628613,0.0001163955,0.00002831605,0.9895763,0.00003299898,0.005288244,0.002613144],"study_design_scores_gemma":[0.0006158154,0.003646753,0.01296531,0.000005355167,0.00001316366,0.0001222564,0.00001234758,0.0000213716,0.9331616,0.0004506206,0.04886517,0.0001202159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939798,0.0008780354,0.0008456308,0.003960268,0.0001124763,0.0001378956,0.000009370938,0.000005488012,0.00007109185],"genre_scores_gemma":[0.9950545,0.0006577345,0.0006611955,0.002904192,0.0005449826,0.000005688335,0.000004247786,0.00003423005,0.000133251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05641465,"threshold_uncertainty_score":0.4092302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189499102939594,"score_gpt":0.276504104306024,"score_spread":0.2646091132766281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}