{"id":"W2126689331","doi":"10.1016/j.jaad.2012.10.055","title":"OBSERVE-5 interim analysis: An observational postmarketing safety registry of etanercept for the treatment of psoriasis","year":2013,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Novartis; Amgen","keywords":"Medicine; Etanercept; Postmarketing surveillance; Observational study; Psoriasis; Interim analysis; Interim; Dermatology; Adverse effect; Clinical trial; Pharmacology; Internal medicine; Tumor necrosis factor alpha","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977707,0.0001981165,0.00111509,0.0001826823,0.0001132,0.000004343892,0.0007157013,0.0001655734,0.0001058847],"category_scores_gemma":[0.0001586825,0.000107645,0.0008405315,0.0004417561,0.0007488718,0.0001124298,0.00004707616,0.0001650181,0.000002569943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004969498,"about_ca_system_score_gemma":0.0001012454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000149553,"about_ca_topic_score_gemma":0.00001171882,"domain_scores_codex":[0.9976467,0.0006847561,0.001188497,0.0001560691,0.00008890277,0.0002349968],"domain_scores_gemma":[0.9947662,0.001363707,0.003332276,0.0002919896,0.0002158989,0.0000298818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005921761,0.001751855,0.5407854,0.0001049251,0.02702738,0.000003806974,0.002682062,0.0004594206,0.3328224,0.0008524509,0.002506785,0.08508166],"study_design_scores_gemma":[0.002438718,0.001074425,0.9011934,0.00004847886,0.004674876,0.0005143039,0.002162833,0.00009471732,0.08101894,0.0002443599,0.006377676,0.0001572959],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909601,0.002736299,0.0002120513,0.005432247,0.0002330726,0.0002725935,0.0001164451,0.00000461418,0.00003257599],"genre_scores_gemma":[0.9971622,0.001121588,0.001296872,0.0001911691,0.00004827374,0.00001827167,0.00002045407,0.00001218392,0.000128942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3604079,"threshold_uncertainty_score":0.4389637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05944239180353295,"score_gpt":0.3224240746200683,"score_spread":0.2629816828165353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}