{"id":"W2126764631","doi":"10.1038/nature06479","title":"Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles","year":2008,"lang":"en","type":"article","venue":"Nature","topic":"Listeria monocytogenes in Food Safety","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Listeriolysin O; Vacuole; Listeria monocytogenes; Microbiology; Phagosome; Biology; Listeria; Intracellular parasite; Bacteria; Intracellular; Pathogen; Macrophage; Phagolysosome; Cytosol; Virology; In vitro; Cell biology; Phagocytosis; Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001887689,0.0002323113,0.0002110058,0.00007098255,0.00009441721,0.00002197951,0.0004260447,0.001370712,0.00002903295],"category_scores_gemma":[0.0001139233,0.0002297717,0.0001090979,0.0001786816,0.00009078822,0.000009559944,0.0002955556,0.0004997064,0.00001995253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004981604,"about_ca_system_score_gemma":0.00007406707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002151572,"about_ca_topic_score_gemma":0.00008657733,"domain_scores_codex":[0.9984401,0.00009163385,0.0003176095,0.0007069238,0.0001573881,0.0002863351],"domain_scores_gemma":[0.9985699,0.000008895908,0.0001122652,0.001155591,0.00007627872,0.00007707681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003051739,0.00006633354,0.01423506,0.00002104197,0.00002847244,0.00004559269,0.0000954579,0.00003676097,0.9799307,0.00005437202,0.002230295,0.002950755],"study_design_scores_gemma":[0.000910325,0.0001622499,0.1001434,0.00002047377,0.00001219235,0.0002367411,0.00002974286,0.00004722189,0.7052885,0.00005363969,0.1926834,0.0004120518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925106,0.004283414,0.0001065759,0.000289852,0.0004016008,0.0002625635,0.0000441349,0.00003245561,0.002068808],"genre_scores_gemma":[0.9939988,0.0006786978,0.001711059,0.001302287,0.0003888976,0.00005192373,0.0003457064,0.00004330102,0.001479302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2746422,"threshold_uncertainty_score":0.9999257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04943516192633679,"score_gpt":0.3302503912768205,"score_spread":0.2808152293504838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}