{"id":"W2126816965","doi":"10.2174/15672018113109990038","title":"Pharmacokinetics of 3&amp;#8217;-O-Retinoyl-5-fluoro-2&amp;#8217;-deoxyuridine (RFUdR), a Dual Acting Mutually Masking Prodrug, and Its Metabolites in Tumor Bearing Mice","year":2013,"lang":"en","type":"article","venue":"Current Drug Delivery","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Energy","funders":"Canadian Institutes of Health Research","keywords":"Prodrug; Pharmacokinetics; Deoxyuridine; Chemistry; Bolus (digestion); Metabolite; Pharmacology; Bioavailability; Retinoic acid; Oral administration; High-performance liquid chromatography; Active metabolite; Medicine; Internal medicine; Biochemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004778247,0.0004427246,0.0004641649,0.0001810815,0.0001169044,0.0001045501,0.0003668999,0.0001357561,0.00005463205],"category_scores_gemma":[0.0003725533,0.0004386495,0.0001428352,0.0002792204,0.0001421082,0.00005479513,0.0004919999,0.0004317455,0.00002675628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003922813,"about_ca_system_score_gemma":0.0001783815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006527157,"about_ca_topic_score_gemma":0.00002306785,"domain_scores_codex":[0.9973332,0.0001598386,0.0007248968,0.0007659919,0.0003464935,0.0006695764],"domain_scores_gemma":[0.9986255,0.00009042919,0.000362863,0.000360773,0.0003724772,0.0001879352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006828378,0.0001647817,0.006314777,0.0007032605,0.00007103178,0.000004439553,0.0006032218,0.00009354941,0.9808454,0.00003040958,0.0005306606,0.01057021],"study_design_scores_gemma":[0.001254293,0.00005150914,0.0008826187,0.0003310484,0.0001170321,0.00004595896,0.000381336,0.0005447497,0.9630892,0.00009199554,0.03257467,0.0006355984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595429,0.03880044,0.0002225298,0.00008864754,0.0004270098,0.0005417609,0.00002886566,0.00003231563,0.0003155099],"genre_scores_gemma":[0.9932705,0.003995242,0.001403077,0.0000704056,0.0005162297,0.00008605312,0.0001642678,0.00006384624,0.0004304383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0348052,"threshold_uncertainty_score":0.9998065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188955237968077,"score_gpt":0.2696374619946643,"score_spread":0.2507419381978566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}