{"id":"W2126844487","doi":"10.1007/s00401-015-1412-5","title":"Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death","year":2015,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Temerty Family Foundation","keywords":"Amyotrophic lateral sclerosis; Frontotemporal lobar degeneration; Neurodegeneration; Motor neuron; Biology; RNA splicing; Cytoplasmic inclusion; Cytoplasm; C9orf72; Inclusion bodies; Alternative splicing; Molecular biology; Cell biology; Spinal cord; Messenger RNA; Gene; Frontotemporal dementia; Biochemistry; Pathology; Neuroscience; Medicine; Allele; Trinucleotide repeat expansion; Disease; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816687,0.0003190034,0.0001939163,0.0002414512,0.0001612377,0.0002711195,0.0001626056,0.0004102308,0.0005910025],"category_scores_gemma":[0.0001667092,0.0001441741,0.0002118017,0.0001652333,0.0002671207,0.0002053747,0.0001703852,0.0004597157,0.0004483502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446843,"about_ca_system_score_gemma":0.0001608403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004643007,"about_ca_topic_score_gemma":0.0005580218,"domain_scores_codex":[0.9998597,0.00002077456,0.00002174872,0.0000369839,0.00004548924,0.00001529589],"domain_scores_gemma":[0.9998566,0.00001623736,0.0000602504,0.00001386792,0.00001945195,0.00003366462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002833985,0.000007890157,0.0001723324,0.00001516857,0.000004233393,0.00009489254,0.00001123222,0.00001562837,0.9991769,0.00005526968,0.0000127255,0.0004052698],"study_design_scores_gemma":[0.0000149059,0.000198771,0.01085982,0.000007958751,0.00004163602,0.002739701,0.0000395251,0.0007986073,0.9823292,0.0002158398,0.00274646,0.000007589377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933235,0.001281386,0.004392483,0.00008785028,0.00002924412,0.00002509326,0.0001685477,0.00007419872,0.0006176052],"genre_scores_gemma":[0.9899374,0.0007113511,0.006818783,0.0001086439,0.00001431042,0.00002841979,0.0007634938,0.0000294051,0.001588126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005910025,"threshold_uncertainty_score":0.001977146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04379419075772097,"score_gpt":0.2682296665340463,"score_spread":0.2244354757763253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}