{"id":"W2126844487","doi":"10.1007/s00401-015-1412-5","title":"Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death","year":2015,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Temerty Family Foundation","keywords":"Amyotrophic lateral sclerosis; Frontotemporal lobar degeneration; Neurodegeneration; Motor neuron; Biology; RNA splicing; Cytoplasmic inclusion; Cytoplasm; C9orf72; Inclusion bodies; Alternative splicing; Molecular biology; Cell biology; Spinal cord; Messenger RNA; Gene; Frontotemporal dementia; Biochemistry; Pathology; Neuroscience; Medicine; Allele; Trinucleotide repeat expansion; Disease; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005580464,0.0003212421,0.0006252441,0.0003789355,0.00008112936,0.00004080417,0.0002903957,0.0001903384,0.00004352567],"category_scores_gemma":[0.000571053,0.0002522843,0.00007603859,0.0006708293,0.0002226249,0.000228504,0.0006520689,0.0007103337,0.000009062034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538834,"about_ca_system_score_gemma":0.00008555914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002453226,"about_ca_topic_score_gemma":0.00001923044,"domain_scores_codex":[0.9969596,0.0004132353,0.0006856593,0.0006551174,0.0005958408,0.0006904906],"domain_scores_gemma":[0.9987757,0.00009102294,0.0001546069,0.0004874022,0.0001559989,0.000335314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006211429,0.0003027355,0.07778263,0.00003248479,0.000005780926,0.00130056,0.0002936141,0.00003154475,0.918909,0.0000275959,0.0003130762,0.0003798811],"study_design_scores_gemma":[0.003220048,0.001574906,0.9618583,0.0001949117,0.00001805218,0.000112281,0.00002318277,0.001770195,0.03062844,0.00006959443,0.0002873038,0.0002428186],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953953,0.0002116244,0.00001103022,0.003007952,0.00007453259,0.0006427807,0.00003556785,0.00005646445,0.0005647227],"genre_scores_gemma":[0.9970026,0.001018722,0.0003430462,0.001268536,0.00004665118,0.00003710718,0.00003949695,0.00004880898,0.0001950344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8882805,"threshold_uncertainty_score":0.999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04379419075772097,"score_gpt":0.2682296665340463,"score_spread":0.2244354757763253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}