{"id":"W2126850213","doi":"10.1002/jhet.304","title":"Bis‐8‐hydroxyquinoline and bis‐8‐hydroxyquinaldine <i>N</i>‐substituted amines: A single methyl group structural difference between the two heterocycles, which modulates the antiproliferative effects","year":2010,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Centre National de la Recherche Scientifique","keywords":"Chemistry; Stereochemistry; Methyl group; 8-Hydroxyquinoline; Ring (chemistry); Medicinal chemistry; Group (periodic table); Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006907972,0.0001651083,0.00009340423,0.00008039262,0.00005531263,0.00007984879,0.0002252926,0.0001697447,0.001901957],"category_scores_gemma":[0.00006704978,0.00007691442,0.00008207469,0.00004688348,0.0001058838,0.0001668838,0.00006903324,0.0002161967,0.00040741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000116373,"about_ca_system_score_gemma":0.00008065538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002086293,"about_ca_topic_score_gemma":0.0004309749,"domain_scores_codex":[0.9999582,0.000009408542,0.000002648871,0.000008299913,0.00001224852,0.00000927674],"domain_scores_gemma":[0.9999601,0.000006776363,0.00001190495,0.000004381203,0.000006410723,0.00001037839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001332553,0.00001262054,0.00003864527,0.0000386989,0.000002052727,0.00003485415,0.000006399635,0.0000581402,0.9974123,0.0001789188,0.00004713544,0.00203708],"study_design_scores_gemma":[0.00003107587,0.0007134789,0.001044446,0.000005127995,0.000007336678,0.0002865106,0.000008888555,0.0003685785,0.9917411,0.00006373545,0.005724311,0.00000551451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756404,0.003400287,0.006754355,0.0001209657,0.00008988842,0.00006753604,0.0002655829,0.0001424955,0.01351845],"genre_scores_gemma":[0.9914694,0.0009782433,0.00398193,0.0000757579,0.00001682676,0.00003075954,0.0002335941,0.0000210467,0.003192338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901957,"threshold_uncertainty_score":0.006362677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215882371992907,"score_gpt":0.2443244417875269,"score_spread":0.2321656180675978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}