{"id":"W2126850213","doi":"10.1002/jhet.304","title":"Bis‐8‐hydroxyquinoline and bis‐8‐hydroxyquinaldine <i>N</i>‐substituted amines: A single methyl group structural difference between the two heterocycles, which modulates the antiproliferative effects","year":2010,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Centre National de la Recherche Scientifique","keywords":"Chemistry; Stereochemistry; Methyl group; 8-Hydroxyquinoline; Ring (chemistry); Medicinal chemistry; Group (periodic table); Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003458696,0.0005897449,0.0009030528,0.00004257152,0.0004500209,0.0002545653,0.0009981359,0.0003609015,0.0001146992],"category_scores_gemma":[0.0007831958,0.0002864886,0.0003255825,0.0002361306,0.0005827643,0.0002322832,0.0003088485,0.00174424,0.000001393411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000626823,"about_ca_system_score_gemma":0.00002460883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003841787,"about_ca_topic_score_gemma":0.0000428077,"domain_scores_codex":[0.9973378,0.0001207507,0.0009022923,0.0005143686,0.0005527593,0.0005720814],"domain_scores_gemma":[0.9962547,0.001665871,0.0009693381,0.0006276284,0.0002056085,0.0002768832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101059,0.0001306827,0.03575262,0.0001480462,0.0002488917,0.00002488579,0.00007275859,0.000007813917,0.9585923,0.000004462849,0.00001427157,0.004902218],"study_design_scores_gemma":[0.001236195,0.00009033581,0.03245708,0.0001700336,0.0002063089,0.0007387677,0.00005794423,0.0003933537,0.963478,0.0003337223,0.0004543112,0.000383978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976688,0.0008150139,0.00007619404,0.0007987993,0.000205695,0.0001430475,0.00004169733,0.00004950575,0.0002012731],"genre_scores_gemma":[0.9977202,0.00008944764,0.0002441462,0.0001013561,0.001733279,0.00001586933,0.00002006169,0.00003523742,0.00004035391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004885677,"threshold_uncertainty_score":0.9999588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215882371992907,"score_gpt":0.2443244417875269,"score_spread":0.2321656180675978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}