{"id":"W2126878782","doi":"10.1183/09031936.00212114","title":"Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis","year":2015,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Murdoch Children's Research Institute; Children’s Hospital of Wisconsin Research Institute; Cystic Fibrosis Foundation Therapeutics","keywords":"Bronchiectasis; Neutrophil elastase; Medicine; Cystic fibrosis; Elastase; Matrix metalloproteinase; Neutrophil extracellular traps; Fibrosis; Pathology; Primary ciliary dyskinesia; Immunology; Internal medicine; Gastroenterology; Lung; Biology; Inflammation; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004897196,0.0003509985,0.0003953639,0.0007080073,0.0001975128,0.00048291,0.0001911916,0.0004246409,0.0008414861],"category_scores_gemma":[0.001465919,0.0002201645,0.000293003,0.0004492872,0.0003029627,0.000294868,0.0002816834,0.0005744477,0.0001727051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002431304,"about_ca_system_score_gemma":0.0002580586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001725478,"about_ca_topic_score_gemma":0.00206965,"domain_scores_codex":[0.9997296,0.00007346992,0.00002738224,0.00005162928,0.0000694234,0.00004839209],"domain_scores_gemma":[0.9983094,0.0003153808,0.0009226016,0.00005488939,0.0001720222,0.000225828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003177918,0.00005374147,0.9815941,0.0000561554,0.00004009691,0.0005467067,0.000108365,0.00005335709,0.01216551,0.00002124563,0.00006023538,0.00498259],"study_design_scores_gemma":[0.000001992372,0.00006730412,0.9982762,0.000008716336,0.00001574431,0.0008586327,0.00004986154,0.00009855342,0.0005232453,0.00001703057,0.00008098291,0.000001688117],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971649,0.002336878,0.0001996566,0.00004333244,0.000004498842,0.000007747916,0.00006668948,0.000008309274,0.0001680056],"genre_scores_gemma":[0.9989952,0.0005298091,0.0002360161,0.0000129846,0.000009152614,0.000004428528,0.00007705027,0.000002179653,0.0001331563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001725478,"threshold_uncertainty_score":0.003430903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.023871523733348,"score_gpt":0.3214444156667868,"score_spread":0.2975728919334388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}