{"id":"W2126932701","doi":"10.1194/jlr.m005702","title":"Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells","year":2010,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Autophagy; Cell biology; Endoplasmic reticulum; Vacuole; Programmed cell death; Downregulation and upregulation; Mitochondrion; Organelle; Apoptosis; Chemistry; Unfolded protein response; Cell; Foam cell; Biology; Cholesterol; Cytoplasm; Biochemistry; Lipoprotein","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002366517,0.0003025038,0.0004330662,0.0003082863,0.0003018729,0.0002372782,0.0001099123,0.0004209342,0.0005206274],"category_scores_gemma":[0.0001071301,0.000093041,0.0004302816,0.0001649983,0.0002345787,0.0002403223,0.0002346154,0.0003582119,0.0001342416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001870877,"about_ca_system_score_gemma":0.0002151302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004032037,"about_ca_topic_score_gemma":0.0006221107,"domain_scores_codex":[0.9998385,0.00003337401,0.00002170028,0.00002729379,0.00003229569,0.00004689903],"domain_scores_gemma":[0.9999071,0.00001103852,0.00002564405,0.00001282838,0.00002028433,0.00002314773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005719088,0.00004941575,0.001628285,0.0002299051,0.00002833027,0.0004536065,0.00009595951,0.00004433043,0.9928918,0.0001431366,0.00007404992,0.003789321],"study_design_scores_gemma":[0.00006010519,0.001378307,0.08180019,0.0000664226,0.0001460409,0.001634175,0.0003127178,0.001239645,0.9073718,0.00038975,0.005578101,0.00002266342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834934,0.01349053,0.001649331,0.0001649116,0.00007485191,0.00002750367,0.0001363871,0.00004067346,0.0009225017],"genre_scores_gemma":[0.9947492,0.003039488,0.0009851806,0.00009469954,0.00003340353,0.00002901546,0.0001315145,0.00000452216,0.0009328984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005206274,"threshold_uncertainty_score":0.001741648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04301660965776552,"score_gpt":0.3639356620689866,"score_spread":0.3209190524112211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}