{"id":"W2126940472","doi":"10.1128/jvi.00508-10","title":"Importin α3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and Replication","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Université du Québec à Montréal; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Biology; Integrase; Nuclear transport; Viral replication; Importin; Small hairpin RNA; HIV Long Terminal Repeat; Virology; Nuclear localization sequence; Gene knockdown; Cell biology; Reverse transcriptase; RNA interference; Molecular biology; Cell nucleus; RNA; Long terminal repeat; Virus; Cell culture; Human immunodeficiency virus (HIV); Genetics; Gene; Gene expression; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009782784,0.0002860681,0.0001405803,0.0001358767,0.0003001501,0.0003169992,0.0001398531,0.0002129075,0.0008013364],"category_scores_gemma":[0.000131085,0.0001161571,0.0002545949,0.000156583,0.0001766099,0.0001974543,0.0002256505,0.0003551949,0.000470973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004064547,"about_ca_system_score_gemma":0.000128653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007470385,"about_ca_topic_score_gemma":0.0006228241,"domain_scores_codex":[0.9999206,0.00001192766,0.000007427472,0.00001935663,0.00002312747,0.00001753765],"domain_scores_gemma":[0.9999255,0.000007706362,0.00002746361,0.000007095859,0.000008608094,0.00002371095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002181635,0.00001785563,0.001867085,0.00003820552,0.000006812296,0.0002101825,0.00002954347,0.00007455002,0.9953452,0.0001141363,0.00006775375,0.00201049],"study_design_scores_gemma":[0.00003639116,0.0001863278,0.07261422,0.00002791048,0.00005591811,0.002231603,0.0001524807,0.004925304,0.9091906,0.0003072799,0.01025693,0.00001501459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942386,0.002079589,0.002003913,0.0001575273,0.00001974393,0.00001068625,0.0001488418,0.0000574329,0.001283599],"genre_scores_gemma":[0.9947739,0.001042769,0.001303541,0.00006642863,0.00001336903,0.000007812392,0.0004275638,0.00001353852,0.002350923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008013364,"threshold_uncertainty_score":0.002949059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005536706836616305,"score_gpt":0.2572751271354249,"score_spread":0.2517384202988086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}