{"id":"W2126975763","doi":"10.1084/jem.20101321","title":"Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90","year":2010,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique; Hôpital Maisonneuve-Rosemont; Université de Montréal; Montreal Clinical Research Institute","funders":"U.S. Public Health Service; Canada Research Chairs; Fondation Jean-Louis Lévesque; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Somatic hypermutation; Activation-induced (cytidine) deaminase; Immunoglobulin class switching; Hsp90; Biology; Heat shock protein; Antibody; Mutation; Germinal center; Gene; Molecular biology; Cell biology; B cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006740043,0.00005978386,0.0001009216,0.0000333185,0.00005678912,0.000002586417,0.0001189252,0.0000548372,0.00006896575],"category_scores_gemma":[0.0002168852,0.0000381742,0.00001792569,0.00005387459,0.0001760032,0.000009047607,0.00004630837,0.0001194679,3.377428e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001370771,"about_ca_system_score_gemma":0.00003531849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004080262,"about_ca_topic_score_gemma":0.00000128985,"domain_scores_codex":[0.9993114,0.00009204951,0.000221095,0.00007276177,0.0002288863,0.00007373297],"domain_scores_gemma":[0.9994175,0.00003210079,0.0001579775,0.0001803623,0.0001493886,0.00006264152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002540281,0.00006967601,0.0009124615,0.000005098844,0.00001625553,1.847283e-7,0.0003407332,2.975083e-7,0.9977362,0.000009126898,0.0002056598,0.0004502712],"study_design_scores_gemma":[0.0006768416,0.0007476212,0.008874753,0.00001355496,0.000008569149,0.00002289445,0.0007785218,0.00002391785,0.9886074,0.00001130447,0.0002007724,0.00003387114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980133,0.0003962185,0.000652561,0.0006438751,0.00005397868,0.0001460789,0.000002816176,9.374585e-7,0.00009020278],"genre_scores_gemma":[0.9995487,0.00005405357,0.0001803575,0.0000252492,0.000142248,0.000001301921,0.0000219174,0.000005414621,0.00002073174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009128829,"threshold_uncertainty_score":0.1556699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289218358127122,"score_gpt":0.3347419303108252,"score_spread":0.311849746729554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}