{"id":"W2126994657","doi":"10.1152/ajplung.2001.280.5.l947","title":"Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion","year":2001,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; St. Michael's Hospital","funders":"","keywords":"Bronchoalveolar lavage; Lung; Neutrophil elastase; Defensin; Medicine; Inflammation; Elastase; Immunology; Tumor necrosis factor alpha; Vascular permeability; Pathology; Chemistry; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004505989,0.0007960807,0.0007038105,0.0004073123,0.0001244919,0.000278479,0.0002151165,0.0005696054,0.001650026],"category_scores_gemma":[0.0003265522,0.000291529,0.0003612133,0.0002487141,0.0003345828,0.0002706703,0.0004485729,0.00082464,0.0005113159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679727,"about_ca_system_score_gemma":0.0001197129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008919287,"about_ca_topic_score_gemma":0.0001870137,"domain_scores_codex":[0.9995725,0.0001593127,0.00003697455,0.00007157573,0.00009361598,0.00006610071],"domain_scores_gemma":[0.9994687,0.00008857638,0.0002329274,0.000058063,0.00005722849,0.00009453479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001636823,0.0004200156,0.008658168,0.0004777167,0.00008447952,0.0007576918,0.0000800174,0.0001518268,0.9759042,0.0001295472,0.0003486108,0.0113508],"study_design_scores_gemma":[0.0003151123,0.01911788,0.3307177,0.0001709076,0.0002676284,0.007531077,0.0002693736,0.001858088,0.6293376,0.000483808,0.009890176,0.00004060631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662202,0.02712766,0.003255897,0.0001857935,0.0000892536,0.0002107245,0.0003307898,0.0001569811,0.002422719],"genre_scores_gemma":[0.9887088,0.006328218,0.002164735,0.0003186423,0.00007149627,0.0001469647,0.0003272666,0.00001043298,0.001923469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001650026,"threshold_uncertainty_score":0.005519927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002994094164744258,"score_gpt":0.200112560431838,"score_spread":0.1971184662670938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}