{"id":"W2127004208","doi":"10.1124/dmd.115.063776","title":"Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of California, Davis; Public Health Agency","keywords":"Epoxide hydrolase 2; Metabolite; Cytochrome P450; Epoxygenase; Arachidonic acid; In vivo; Internal medicine; Endocrinology; CYP3A; Chemistry; Muscle hypertrophy; Pharmacology; Biology; Biochemistry; Metabolism; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004014953,0.0001469738,0.0002929989,0.00009454445,0.00004490102,0.00002648687,0.00008347261,0.0001398446,0.000001756856],"category_scores_gemma":[0.00004720482,0.0001049022,0.00003869205,0.0001330323,0.00005453679,0.0000199333,0.00005507893,0.0001224842,4.39507e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006149038,"about_ca_system_score_gemma":0.00003001987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002640859,"about_ca_topic_score_gemma":0.0001316613,"domain_scores_codex":[0.9989426,0.0003535344,0.0001927278,0.0002367714,0.0001004734,0.0001739433],"domain_scores_gemma":[0.9996452,0.00002100574,0.0001014997,0.0001162324,0.00006203418,0.00005397357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001330822,0.0001105404,0.001442972,0.000005980542,0.00002872405,7.979618e-7,0.001850166,6.187669e-7,0.99367,0.0001040592,0.00006745117,0.002585536],"study_design_scores_gemma":[0.00220145,0.0002448675,0.3472444,0.00001950974,0.00009220236,0.00000595704,0.00107576,0.00007437233,0.647181,0.0006870125,0.0009360296,0.0002373665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847429,0.01430809,0.000007214976,0.0003232486,0.00007243786,0.000314862,0.0001590236,0.000004569588,0.00006766499],"genre_scores_gemma":[0.9982554,0.0007916671,0.00001792013,0.0004442488,0.0001139575,0.00007976728,0.0002806895,0.00001097246,0.000005370783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.346489,"threshold_uncertainty_score":0.4277787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047384249749013,"score_gpt":0.2324129126672984,"score_spread":0.2219390701698083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}