{"id":"W2127015328","doi":"10.1128/mcb.00396-10","title":"The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression","year":2010,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of General Medical Sciences; University of California, San Francisco","keywords":"Biology; Deubiquitinating enzyme; Transcription factor; YY1; Transcriptional regulation; Regulation of gene expression; Cell biology; BAP1; Ubiquitin; Promoter; Gene expression; Gene; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002213486,0.0002064913,0.0002142686,0.00003099226,0.0001790883,0.00002958687,0.0001332964,0.0002505765,0.0000126718],"category_scores_gemma":[0.00005478022,0.0001343469,0.00004930293,0.00003828499,0.0007583878,0.000004262797,0.0001966303,0.0001693177,5.429111e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001793685,"about_ca_system_score_gemma":0.00003169703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002050745,"about_ca_topic_score_gemma":0.00001468049,"domain_scores_codex":[0.9988893,0.00009622883,0.0002026921,0.0004334942,0.00008271012,0.0002955344],"domain_scores_gemma":[0.9993148,0.00003515743,0.00007120042,0.0003637681,0.00006046804,0.0001545959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001689955,0.00002698265,0.00281603,0.00003724418,0.00003401861,0.00001667602,0.00006173569,1.609973e-7,0.9937724,0.001541195,0.00003122414,0.001493278],"study_design_scores_gemma":[0.0006502919,0.0007034761,0.0005298461,0.00001468027,0.00002981962,0.0001866618,0.0000725325,0.0001536693,0.9900938,0.0008890693,0.006478617,0.0001974932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930913,0.003315477,0.002464777,0.0003689895,0.00003627269,0.0002255507,0.00004955816,0.000008348476,0.0004397402],"genre_scores_gemma":[0.9970923,0.0001485874,0.002207046,0.0003203581,0.00006377983,0.00003016058,0.00006548054,0.00002361204,0.00004868962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006447393,"threshold_uncertainty_score":0.5478509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006431495402145166,"score_gpt":0.2294509210641391,"score_spread":0.2230194256619939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}