{"id":"W2127057372","doi":"10.1002/chem.201003432","title":"Targeting Norovirus Infection—Multivalent Entry Inhibitor Design Based on NMR Experiments","year":2011,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Norovirus; Avidity; Surface plasmon resonance; Chemistry; Murine norovirus; Ligand (biochemistry); Binding site; Viral entry; Rational design; Stereochemistry; Virology; Biochemistry; Virus; Antigen; Biology; Nanotechnology; Viral replication; Immunology; Receptor; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009914456,0.0002106782,0.0002575698,0.0000590211,0.0001879743,0.00003268032,0.0001432614,0.00004569298,0.001902446],"category_scores_gemma":[0.0008301823,0.0001762089,0.0001607501,0.00006647807,0.0001030097,0.00007047387,0.00006248528,0.0007821552,0.0002034194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568094,"about_ca_system_score_gemma":0.00008453492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000468436,"about_ca_topic_score_gemma":2.919369e-8,"domain_scores_codex":[0.9979066,0.0005353771,0.0004622995,0.0002774668,0.0002833864,0.0005348558],"domain_scores_gemma":[0.9988624,0.00002389812,0.0001766229,0.0002158124,0.0001131524,0.0006081145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003143445,0.001011086,0.03567178,0.0001317226,0.0001189652,0.00388933,0.0002695122,0.0003729724,0.9110358,2.957197e-7,0.03818103,0.006173999],"study_design_scores_gemma":[0.03071729,0.01004712,0.09342975,0.003362866,0.0001992806,0.006722652,0.0006710939,0.03936188,0.7693318,0.00002944435,0.04470606,0.00142083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698007,0.0001766003,0.01357031,0.000219212,0.0002623397,0.0002003842,0.000006096595,0.00008430373,0.01568005],"genre_scores_gemma":[0.99214,0.0001288302,0.005235541,0.0005464327,0.001045486,0.000006729818,0.0000142936,0.00004801109,0.0008346516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1417041,"threshold_uncertainty_score":0.99901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0879442151756358,"score_gpt":0.3059123667762759,"score_spread":0.2179681516006401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}