{"id":"W2127057372","doi":"10.1002/chem.201003432","title":"Targeting Norovirus Infection—Multivalent Entry Inhibitor Design Based on NMR Experiments","year":2011,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Norovirus; Avidity; Surface plasmon resonance; Chemistry; Murine norovirus; Ligand (biochemistry); Binding site; Viral entry; Rational design; Stereochemistry; Virology; Biochemistry; Virus; Antigen; Biology; Nanotechnology; Viral replication; Immunology; Receptor; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002950153,0.0005547569,0.0005011327,0.0002257753,0.0001661603,0.0005011855,0.0004724491,0.0002390615,0.0007894427],"category_scores_gemma":[0.0002351894,0.0001962504,0.0002100585,0.0001232156,0.0002433943,0.0002656623,0.0003048059,0.0004494317,0.0002528592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005749379,"about_ca_system_score_gemma":0.0002763354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006962801,"about_ca_topic_score_gemma":0.001217993,"domain_scores_codex":[0.9998564,0.00002464878,0.00001014138,0.00003364509,0.00004183029,0.00003341958],"domain_scores_gemma":[0.9998932,0.00002071049,0.00002483174,0.000009388928,0.00002648351,0.00002544583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001856288,0.00008578505,0.00009852372,0.00006633015,0.00001049926,0.00003717695,0.00002062636,0.001589838,0.9914412,0.0005166958,0.00007776154,0.005869844],"study_design_scores_gemma":[0.00005200128,0.0008115815,0.0001590245,0.000005659425,0.00002725999,0.00008955194,0.00000979955,0.004427866,0.9906631,0.00007408967,0.003668912,0.00001120025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441103,0.003555551,0.04517007,0.0002609941,0.00008044441,0.0004450709,0.0003432627,0.0002676761,0.005766581],"genre_scores_gemma":[0.9714215,0.002299395,0.02185689,0.0001039794,0.00002231554,0.0001430619,0.0003244844,0.00003008106,0.003798286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007894427,"threshold_uncertainty_score":0.004171431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0879442151756358,"score_gpt":0.3059123667762759,"score_spread":0.2179681516006401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}