{"id":"W2127072493","doi":"10.1128/mmbr.00020-07","title":"The Membrane-Proximal External Region of the Human Immunodeficiency Virus Type 1 Envelope: Dominant Site of Antibody Neutralization and Target for Vaccine Design","year":2008,"lang":"en","type":"review","venue":"Microbiology and Molecular Biology Reviews","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"U.S. Public Health Service","keywords":"Gp41; Biology; Virology; Epitope; Neutralization; Antibody; Human immunodeficiency virus (HIV); Viral envelope; Computational biology; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003441556,0.0006812013,0.001132574,0.0008560671,0.0001888886,0.0006156986,0.0007184825,0.0009195909,0.002222467],"category_scores_gemma":[0.0002231483,0.0002018839,0.0002442882,0.0008049032,0.0003195961,0.0008288354,0.0003058212,0.0008974172,0.00328319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005507022,"about_ca_system_score_gemma":0.0005559762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004511553,"about_ca_topic_score_gemma":0.0007071249,"domain_scores_codex":[0.9999039,0.00001631293,0.000008122569,0.00001687238,0.00004192866,0.00001285511],"domain_scores_gemma":[0.9999273,0.00002327776,0.00001290772,0.000002513946,0.0000213004,0.00001273466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008850206,0.00007406369,0.0001659624,0.007211122,0.00002889796,0.0003569771,0.00005041801,0.0004701876,0.02575658,0.006204278,0.01477953,0.9448134],"study_design_scores_gemma":[0.00002608739,0.000191871,0.0006534643,0.001187646,0.00004210061,0.002366385,0.00006279042,0.0001506327,0.006261067,0.002526957,0.986516,0.00001499491],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006845423,0.9957873,0.0006856877,0.0002555115,0.0002513365,0.00001142749,0.00001477045,0.00001397905,0.002295508],"genre_scores_gemma":[0.002298957,0.9937874,0.00118752,0.000183391,0.0001420183,0.00001568003,0.00003345392,0.000002276444,0.00234939],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002222467,"threshold_uncertainty_score":0.007434905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03866069328276117,"score_gpt":0.3387040204903889,"score_spread":0.3000433272076278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}