{"id":"W2127072493","doi":"10.1128/mmbr.00020-07","title":"The Membrane-Proximal External Region of the Human Immunodeficiency Virus Type 1 Envelope: Dominant Site of Antibody Neutralization and Target for Vaccine Design","year":2008,"lang":"en","type":"review","venue":"Microbiology and Molecular Biology Reviews","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"U.S. Public Health Service","keywords":"Gp41; Biology; Virology; Epitope; Neutralization; Antibody; Human immunodeficiency virus (HIV); Viral envelope; Computational biology; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007850383,0.0004853029,0.001927643,0.0001200443,0.000542081,0.000006842175,0.0004594187,0.0007315768,0.00001390881],"category_scores_gemma":[0.0001933857,0.0002366834,0.0004507785,0.0002145857,0.001166468,0.00002122934,0.000261721,0.0003780324,0.00001599834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002365225,"about_ca_system_score_gemma":0.0001701306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003169849,"about_ca_topic_score_gemma":0.000008479939,"domain_scores_codex":[0.9954273,0.002406627,0.001096214,0.0005622421,0.00001635869,0.0004913155],"domain_scores_gemma":[0.9979392,0.0003594673,0.0009623236,0.0005839885,0.0001291356,0.00002586978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001656693,0.000112379,0.000164302,0.001820017,0.0004789709,0.000006951972,0.00006331641,1.780383e-7,0.9163309,0.0007342556,0.0004636821,0.07965941],"study_design_scores_gemma":[0.0009846442,0.0008957264,0.00003986207,0.001430766,0.0004852061,0.001358531,0.000003227639,1.987701e-7,0.03345028,0.00007630735,0.9610283,0.0002469851],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002948287,0.991255,0.002278286,0.00003383838,0.0002475804,0.002996881,0.0002227138,0.000006738742,0.0000107048],"genre_scores_gemma":[0.00119568,0.9968622,0.0003445233,0.00003074886,0.00001314642,0.0001765728,0.00114134,0.00002733872,0.0002084032],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9605646,"threshold_uncertainty_score":0.965167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03866069328276117,"score_gpt":0.3387040204903889,"score_spread":0.3000433272076278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}