{"id":"W2127080406","doi":"10.1128/aac.49.5.1745-1752.2005","title":"<i>Candida albicans</i> Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; McGill University; Royal Victoria Hospital","funders":"Pfizer Canada","keywords":"Ergosterol; Biology; Ketoconazole; Candida albicans; Azole; Microbiology; Antifungal drug; Gene; Corpus albicans; Fluconazole; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830035,0.0002805828,0.0005035496,0.00008292371,0.0001270975,0.00004864633,0.000115864,0.0001388641,0.0003056586],"category_scores_gemma":[0.000009691759,0.0002358787,0.0000914121,0.0001322966,0.0002488692,0.000174093,0.00004146454,0.0001262359,0.000007033717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003593143,"about_ca_system_score_gemma":0.00007256297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008641523,"about_ca_topic_score_gemma":0.0001363403,"domain_scores_codex":[0.9984393,0.0000490993,0.0003778927,0.0005614602,0.0002235005,0.0003487432],"domain_scores_gemma":[0.9991073,0.00002024498,0.0001192469,0.0003901123,0.0001055741,0.0002575005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004354529,0.0005076371,0.04632007,0.000389464,0.0001496481,0.000007541038,0.002415339,4.205891e-7,0.9086076,0.00003809285,0.01185886,0.02535079],"study_design_scores_gemma":[0.00454504,0.0005728387,0.08899274,0.0005535666,0.00008560851,0.00001738962,0.0003906448,0.00003794649,0.7787364,0.00002158146,0.1255585,0.000487822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986879,0.000103795,0.000080306,0.01153422,0.00003585024,0.0008234333,0.00007657098,0.00003014983,0.0004366907],"genre_scores_gemma":[0.9776173,0.0005945588,0.001251188,0.01752388,0.0001347952,0.000009036482,0.000009662827,0.00004204721,0.002817564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1298713,"threshold_uncertainty_score":0.9618856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163096900063498,"score_gpt":0.263765547723296,"score_spread":0.252134578722661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}