{"id":"W2127080406","doi":"10.1128/aac.49.5.1745-1752.2005","title":"<i>Candida albicans</i> Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; McGill University; Royal Victoria Hospital","funders":"Pfizer Canada","keywords":"Ergosterol; Biology; Ketoconazole; Candida albicans; Azole; Microbiology; Antifungal drug; Gene; Corpus albicans; Fluconazole; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006807656,0.0005027576,0.0002228167,0.0004040826,0.0002384332,0.0003330152,0.0003228869,0.0002075233,0.00258251],"category_scores_gemma":[0.0001133371,0.0001078546,0.0002564031,0.0003397209,0.0002036488,0.0001027849,0.0004141151,0.0004691603,0.0007486077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005442361,"about_ca_system_score_gemma":0.0002538159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002761404,"about_ca_topic_score_gemma":0.002085674,"domain_scores_codex":[0.9998444,0.0000116633,0.000009616521,0.00003262197,0.00006449203,0.00003716915],"domain_scores_gemma":[0.9999223,0.000007860362,0.00001807739,0.000008988723,0.00001429569,0.00002843124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009216438,0.00002351415,0.0004001332,0.00002789467,0.000004762105,0.0001116381,0.000006588774,0.00005574582,0.9971775,0.0000948442,0.0002806576,0.001724635],"study_design_scores_gemma":[0.00001587189,0.00007561201,0.01842809,0.00001302012,0.00002328931,0.0009823168,0.00003899499,0.001525556,0.9693484,0.00009839157,0.009438225,0.00001225013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801111,0.00223025,0.007256433,0.000386816,0.00008678532,0.00003512271,0.004451318,0.0006650715,0.004777052],"genre_scores_gemma":[0.9834158,0.0007076926,0.003378676,0.0001294832,0.00001875536,0.0000395313,0.005887889,0.0001053091,0.006316843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002761404,"threshold_uncertainty_score":0.008639395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163096900063498,"score_gpt":0.263765547723296,"score_spread":0.252134578722661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}