{"id":"W2127124250","doi":"10.1101/gad.1453406","title":"E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells","year":2006,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"BMI1; Biology; Haematopoiesis; Gene knockdown; RNA interference; Cell biology; Stem cell; Cancer research; Phenotype; Clonogenic assay; Hematopoietic stem cell; Cell culture; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691783,0.0001504254,0.0001274649,0.00006031494,0.00007883871,0.00002119052,0.00007412862,0.0001152829,0.000008214265],"category_scores_gemma":[0.00001934951,0.0001504187,0.0000431433,0.00007437565,0.00001576433,0.000003257626,0.00005086528,0.0000373137,0.000005039158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004847625,"about_ca_system_score_gemma":0.0001579651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003595953,"about_ca_topic_score_gemma":0.0003143804,"domain_scores_codex":[0.9989673,0.00001718102,0.0003126935,0.0003177773,0.0001247018,0.0002603601],"domain_scores_gemma":[0.9996264,0.00001958862,0.0001032354,0.0001266857,0.00008181496,0.00004230699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003628563,0.00005521554,0.00398116,0.00002813963,0.00001719412,4.080781e-7,0.0001576157,0.0005541738,0.9813653,0.00003595008,0.00003308435,0.01373543],"study_design_scores_gemma":[0.0006391655,0.00006241325,0.06109031,0.00001149182,0.000007427094,5.022877e-7,0.00005058074,0.00007388367,0.9106125,0.00008430233,0.02716393,0.0002035357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9419364,0.001404296,0.05576897,0.00003251756,0.0002540653,0.0003783726,0.00002962719,0.000009608468,0.0001860944],"genre_scores_gemma":[0.9825573,0.0001124222,0.0163744,0.00005361919,0.0001722038,0.0001228198,0.0003466256,0.00002303185,0.0002375724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07075287,"threshold_uncertainty_score":0.6133895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135412770349385,"score_gpt":0.2357383368214197,"score_spread":0.2243842091179259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}