{"id":"W2127124250","doi":"10.1101/gad.1453406","title":"E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells","year":2006,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"BMI1; Biology; Haematopoiesis; Gene knockdown; RNA interference; Cell biology; Stem cell; Cancer research; Phenotype; Clonogenic assay; Hematopoietic stem cell; Cell culture; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001901533,0.0006014781,0.0002617942,0.0003069642,0.000218408,0.0002823747,0.0003179896,0.0003949679,0.002428803],"category_scores_gemma":[0.0002110581,0.0001687243,0.0001859775,0.0001149755,0.0002366747,0.0002962151,0.0002742187,0.0003879037,0.0007267814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003561687,"about_ca_system_score_gemma":0.0001929963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005584264,"about_ca_topic_score_gemma":0.0004417133,"domain_scores_codex":[0.9999282,0.000008939288,0.000004111761,0.00001991451,0.0000191158,0.00001981028],"domain_scores_gemma":[0.9999059,0.00001813314,0.00002330023,0.000007185555,0.000009132589,0.00003633211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008331105,0.0000111241,0.000542591,0.00003211707,0.000003146565,0.0001159449,0.000006851984,0.00005515659,0.9959626,0.0001692973,0.00004409671,0.002973721],"study_design_scores_gemma":[0.00002164463,0.0001061323,0.01122985,0.000005201566,0.00001000939,0.0005853461,0.00001224243,0.0009270389,0.9837239,0.0001070622,0.003265851,0.000005724113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712086,0.004775266,0.01995635,0.000210532,0.00002828931,0.00005952377,0.0005697145,0.0003518049,0.002839882],"genre_scores_gemma":[0.9798869,0.001246799,0.01075772,0.00005315047,0.00001506506,0.0000347162,0.001153741,0.00003877551,0.006813068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002428803,"threshold_uncertainty_score":0.008125126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135412770349385,"score_gpt":0.2357383368214197,"score_spread":0.2243842091179259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}