{"id":"W2127133496","doi":"10.1074/jbc.a114.607359","title":"HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase.","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Aptamer; Thrombin; Chemistry; Oligonucleotide; Surface plasmon resonance; Biophysics; Streptavidin; Molecular biology; Biochemistry; Stereochemistry; DNA; Biology; Nanotechnology; Biotin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003279787,0.0002613215,0.0003702038,0.000033908,0.00006886939,0.00003561052,0.0001543377,0.0003603081,0.000004769418],"category_scores_gemma":[0.0003659943,0.0001644836,0.00008330328,0.0001803528,0.0002279409,0.00001418918,0.00007336088,0.0003129843,8.048461e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004838878,"about_ca_system_score_gemma":0.00008779833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000317803,"about_ca_topic_score_gemma":5.527965e-7,"domain_scores_codex":[0.9987157,0.00008375484,0.0003578363,0.0003559458,0.0002538827,0.0002328691],"domain_scores_gemma":[0.9987072,0.000024095,0.0004748098,0.0001927551,0.0003848491,0.0002162698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006890846,0.0003372743,0.0005830792,0.00001794949,0.00008449787,0.00000832102,0.000009617072,0.000002074021,0.9958493,0.000004069664,0.001882132,0.0005326359],"study_design_scores_gemma":[0.001124039,0.002554021,0.0006058294,0.0001025013,0.00002932357,0.0001565147,0.00005757376,0.000005332154,0.9937314,0.0001342344,0.00124914,0.0002500984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987273,0.0002468783,0.0001150105,0.0003704317,0.00001936607,0.000197466,0.00001834755,0.00004063123,0.0002645466],"genre_scores_gemma":[0.9973201,0.0002235712,0.001875642,0.0001708409,0.0001404954,0.00001064445,0.00008098003,0.00001661638,0.0001610799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002216747,"threshold_uncertainty_score":0.6707447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258790387651903,"score_gpt":0.2612828094430655,"score_spread":0.2386949055665464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}