{"id":"W2127140021","doi":"10.1124/jpet.102.045674","title":"N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2 H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":249,"is_retracted":false,"has_abstract":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Capsazepine; Chemistry; Capsaicin; Antagonist; TRPV1; Pharmacology; Receptor antagonist; Receptor; Biochemistry; Transient receptor potential channel; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134905,0.0003037146,0.0003392191,0.0001461558,0.0001252301,0.0001472498,0.0003064744,0.0002411353,0.0008764667],"category_scores_gemma":[0.0001736797,0.0001416428,0.0001241383,0.0001288673,0.0001678496,0.0002673276,0.0001125524,0.0005598934,0.0004739006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761818,"about_ca_system_score_gemma":0.0003269837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537408,"about_ca_topic_score_gemma":0.002002523,"domain_scores_codex":[0.9999288,0.0000126152,0.00000461003,0.00001057909,0.00002278502,0.00002050366],"domain_scores_gemma":[0.9999439,0.00001195476,0.00001493057,0.000003993436,0.00001150701,0.00001374662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003035089,0.00006732993,0.0000670177,0.00009354818,0.000003415229,0.00006167869,0.00001149245,0.0001090128,0.9930102,0.00006050451,0.0001069492,0.006105239],"study_design_scores_gemma":[0.0003578518,0.006283903,0.005051825,0.00001774334,0.0000655513,0.00188514,0.00003295165,0.00176211,0.9745635,0.00005622552,0.009903161,0.00002016346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530975,0.02455954,0.0133196,0.0006036109,0.0001282517,0.0002882271,0.0006353973,0.0001977694,0.007170044],"genre_scores_gemma":[0.9741537,0.01267882,0.007551773,0.0001592721,0.0001087265,0.0001123369,0.0008424311,0.00002279264,0.00437009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537408,"threshold_uncertainty_score":0.003056884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850566129959074,"score_gpt":0.2782377448469778,"score_spread":0.2597320835473871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}