{"id":"W2127148939","doi":"10.1124/jpet.109.156398","title":"Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Receptor; Ligand (biochemistry); G protein-coupled receptor; Selectivity; Stereochemistry; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007438443,0.0001878449,0.000199352,0.000250419,0.0001457529,0.0004257821,0.0003577465,0.0003321813,0.003538486],"category_scores_gemma":[0.0008756992,0.0001503455,0.0001568335,0.0001109126,0.0003102894,0.0003696058,0.0002137503,0.000377996,0.0005121432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780787,"about_ca_system_score_gemma":0.0002325757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001566035,"about_ca_topic_score_gemma":0.0001316325,"domain_scores_codex":[0.9995899,0.0001904096,0.00003403158,0.00003488137,0.00007102673,0.00007980558],"domain_scores_gemma":[0.9996266,0.0002108092,0.00003398461,0.00003056304,0.00004223805,0.00005585194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001601532,0.00003961489,0.0004558578,0.00007913111,0.000009226389,0.0001112545,0.00003272446,0.0002567685,0.9898592,0.001800122,0.00009524475,0.005659349],"study_design_scores_gemma":[0.000100231,0.001383642,0.002898953,0.00001422374,0.00002712582,0.001492299,0.00006686121,0.001559523,0.9881967,0.0005307823,0.003718224,0.0000115462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896324,0.002217152,0.003484938,0.0001854403,0.00004123741,0.0000228545,0.0002038716,0.00003925272,0.004172848],"genre_scores_gemma":[0.9959295,0.0006967363,0.001293089,0.000108321,0.00001945871,0.00001994191,0.0002411525,0.00001095915,0.001680769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003538486,"threshold_uncertainty_score":0.01183742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286929269770961,"score_gpt":0.2916024742825324,"score_spread":0.2787331815848229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}