{"id":"W2127195471","doi":"10.1242/dev.02171","title":"The homeoprotein engrailed 1 has pleiotropic functions in calvarial intramembranous bone formation and remodeling","year":2005,"lang":"en","type":"article","venue":"Development","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Intramembranous ossification; Calvaria; Biology; Osteoblast; Cell biology; Endochondral ossification; Bone remodeling; Osteoclast; Endocrinology; Internal medicine; Anatomy; Receptor; Medicine; Genetics; Cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101023,0.0003052468,0.0001102418,0.0001814956,0.0001321532,0.0002195668,0.0001185347,0.0001098046,0.0005973408],"category_scores_gemma":[0.000073824,0.0001047155,0.00006917287,0.0000878974,0.0002428554,0.0001140913,0.0002333211,0.0002023799,0.0001634733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002106955,"about_ca_system_score_gemma":0.0001655017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004461752,"about_ca_topic_score_gemma":0.001295257,"domain_scores_codex":[0.9999276,0.000007897109,0.000004203393,0.00001502959,0.0000332546,0.00001203408],"domain_scores_gemma":[0.9999532,0.000006269046,0.00001649297,0.00000378185,0.000004347207,0.00001599734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000055071,0.000003759968,0.0009702484,0.00003063383,0.000003244462,0.00009088006,0.00001036109,0.0001642692,0.9917888,0.0002876085,0.00002917681,0.006565994],"study_design_scores_gemma":[0.00001264002,0.0001507839,0.06706404,0.00001452273,0.00003046196,0.001387835,0.0000650693,0.001277498,0.9186936,0.0003153213,0.01097744,0.00001083483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979031,0.01019378,0.005869812,0.0001284744,0.00001808139,0.00001101855,0.0001992459,0.0001212056,0.004427426],"genre_scores_gemma":[0.9907972,0.004010323,0.001907875,0.00002757196,0.000006469852,0.000006294079,0.0001475951,0.00001416098,0.00308247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005973408,"threshold_uncertainty_score":0.001998246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009817454940822165,"score_gpt":0.2029044677385277,"score_spread":0.1930870127977055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}