{"id":"W2127272421","doi":"10.1016/s0140-6736(12)60768-5","title":"The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial","year":2012,"lang":"en","type":"article","venue":"The Lancet","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":1191,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; Chest Heart and Stroke Scotland; National Health and Medical Research Council; Scottish Funding Council; Norges Forskningsråd; Dalhousie University; Schweizerische Herzstiftung; National Research Foundation; Karolinska Institutet; National Institute for Health and Care Research; University of Edinburgh; Stroke Association; Stockholms Läns Landsting; National Institute for Social Care and Health Research","keywords":"Thrombolysis; Ischaemic stroke; Medicine; Recombinant tissue plasminogen activator; Stroke (engine); Randomized controlled trial; Tissue plasminogen activator; Acute stroke; Clinical trial; Emergency medicine; Intensive care medicine; Internal medicine; Ischemic stroke; Ischemia; Myocardial infarction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004023951,0.003201497,0.006325948,0.0005734892,0.0007879494,0.001929077,0.001881161,0.00528087,0.009729357],"category_scores_gemma":[0.007170694,0.001106874,0.006163998,0.0007909857,0.002741896,0.002341465,0.0009852729,0.006452152,0.001343247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001306745,"about_ca_system_score_gemma":0.001579494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002237577,"about_ca_topic_score_gemma":0.002400237,"domain_scores_codex":[0.9974516,0.001551606,0.0001889494,0.0003768638,0.0001562408,0.0002746767],"domain_scores_gemma":[0.9966348,0.00166767,0.0007447064,0.0003384761,0.000112791,0.0005016235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.99306,0.000873496,0.0002677138,0.0006437888,0.0018482,0.00003051138,0.00003156595,0.0001368411,0.000272766,0.0001360258,0.0003873447,0.002311809],"study_design_scores_gemma":[0.9867007,0.009727056,0.001002429,0.00007332934,0.001636013,0.00002046084,0.00001871853,0.0001695652,0.00006896733,0.0003398868,0.0002239704,0.00001888908],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635948,0.02031401,0.001242994,0.00267336,0.002291835,0.003723199,0.002070125,0.0001728165,0.003916986],"genre_scores_gemma":[0.980283,0.005833013,0.001440941,0.002356301,0.001599633,0.004102359,0.001421311,0.0000389569,0.002924461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009729357,"threshold_uncertainty_score":0.03254795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02067090603183677,"score_gpt":0.2707058974579143,"score_spread":0.2500349914260775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}