{"id":"W2127307813","doi":"10.1534/genetics.111.131227","title":"UNC-73/Trio RhoGEF-2 Activity Modulates <i>Caenorhabditis elegans</i> Motility Through Changes in Neurotransmitter Signaling Upstream of the GSA-1/Gαs Pathway","year":2011,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Caenorhabditis elegans; Biology; Motility; Cell biology; Upstream (networking); Genetics; Neurotransmitter systems; Neurotransmitter; Signal transduction; Mutation; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008750676,0.0003216005,0.0001770317,0.0001861244,0.0002020113,0.0003112612,0.000281284,0.0002592252,0.0007349912],"category_scores_gemma":[0.00007774912,0.0001597863,0.0002024847,0.00008687411,0.0002977798,0.0001510911,0.0001572625,0.0005792298,0.0002137367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006031296,"about_ca_system_score_gemma":0.0002378667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002758797,"about_ca_topic_score_gemma":0.005859606,"domain_scores_codex":[0.9998672,0.00001309603,0.0000110812,0.00002824938,0.00002783288,0.00005241754],"domain_scores_gemma":[0.9998966,0.000009061054,0.00003236254,0.000008595885,0.000008433854,0.00004484096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001020872,0.00002444066,0.0001587618,0.00001631923,0.000002690975,0.00002758458,0.00001013462,0.00004237547,0.9991977,0.00004444636,0.00004389566,0.0003296444],"study_design_scores_gemma":[0.00002722473,0.00027866,0.0232528,0.00001300153,0.00002779088,0.0001084092,0.00006315384,0.001747773,0.9726411,0.00003396739,0.0017915,0.00001456404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974478,0.0003188449,0.0004085265,0.00006721256,0.00001311277,0.00001337266,0.0002892901,0.00008304109,0.001358683],"genre_scores_gemma":[0.9974355,0.0002678639,0.0005646541,0.00006323183,0.000005117782,0.00003182029,0.0002817387,0.00002570239,0.001324474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002758797,"threshold_uncertainty_score":0.005485475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02274875367515079,"score_gpt":0.2110410519280921,"score_spread":0.1882922982529413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}