{"id":"W2127371447","doi":"10.2337/db13-1777","title":"A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":320,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Autoimmunity; Immunology; Autoantibody; Biology; Interferon; Type 1 diabetes; Gene signature; Interferon type I; Gene; Autoimmune disease; CD14; Microarray analysis techniques; Immune system; Gene expression; Antibody; Diabetes mellitus; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002946935,0.0002066806,0.0002210877,0.0000526928,0.0001047326,0.00003292921,0.0002385982,0.0002637331,0.00004880328],"category_scores_gemma":[0.0003425813,0.0001977098,0.0001189025,0.0001276495,0.00008603024,0.000005878487,0.00007855494,0.0001535432,0.00001439957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002388001,"about_ca_system_score_gemma":0.00003165524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007511601,"about_ca_topic_score_gemma":0.00002911352,"domain_scores_codex":[0.9987711,0.0001214627,0.0002100967,0.0003476585,0.00009955558,0.0004501822],"domain_scores_gemma":[0.9994371,0.00006163509,0.00008026777,0.0002419201,0.0001089151,0.00007018726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005853482,0.0001223341,0.5158171,0.00001664949,0.0001418513,1.323065e-8,0.00003004137,0.0001550595,0.4769102,0.00006508889,0.001120627,0.005562447],"study_design_scores_gemma":[0.002008464,0.002040779,0.7399471,0.00005857582,0.0001028957,1.089561e-7,0.00002167871,0.001976381,0.2356894,0.001271118,0.01624955,0.0006339579],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962121,0.002761078,0.00002470993,0.00008841263,0.0001728529,0.0003105701,0.0001123667,0.00002452986,0.0002933944],"genre_scores_gemma":[0.9976596,0.0001732613,0.0003725478,0.0003270028,0.0001164024,0.0000474551,0.001035438,0.00003709342,0.0002312106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2412208,"threshold_uncertainty_score":0.806237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006029586947192631,"score_gpt":0.2209319015954744,"score_spread":0.2149023146482818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}