{"id":"W2127371447","doi":"10.2337/db13-1777","title":"A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":320,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Autoimmunity; Immunology; Autoantibody; Biology; Interferon; Type 1 diabetes; Gene signature; Interferon type I; Gene; Autoimmune disease; CD14; Microarray analysis techniques; Immune system; Gene expression; Antibody; Diabetes mellitus; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001641875,0.0002753214,0.0003114705,0.0005227086,0.0002835436,0.0004354722,0.0001821793,0.0004028472,0.001376062],"category_scores_gemma":[0.0008547042,0.0002563912,0.0002816069,0.0005363917,0.0002550183,0.0001638817,0.0002778818,0.000596014,0.0002047264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002337647,"about_ca_system_score_gemma":0.000188235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002335545,"about_ca_topic_score_gemma":0.002260773,"domain_scores_codex":[0.9997275,0.00004366986,0.00001487174,0.0001210859,0.00004743981,0.0000454086],"domain_scores_gemma":[0.9992774,0.000178324,0.0003410006,0.00003849641,0.00004533434,0.0001192858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006723546,0.00004582714,0.9670091,0.00002175431,0.00004241294,0.0005297725,0.0003200341,0.00009528461,0.02866073,0.00004160561,0.0001049987,0.002456004],"study_design_scores_gemma":[0.0000030743,0.00006591429,0.9985049,0.000003163656,0.00001533727,0.0004977776,0.00007886266,0.00006875127,0.0006572131,0.00001520053,0.00008752527,0.000002373212],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995878,0.00008978825,0.00006681176,0.00001239989,0.000002466396,0.000001432933,0.0001180825,0.000003600563,0.0001174434],"genre_scores_gemma":[0.9993617,0.0001023483,0.0001446443,0.00001959444,0.000005862789,0.000004686118,0.0002084466,0.000004471329,0.0001483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002335545,"threshold_uncertainty_score":0.004643917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006029586947192631,"score_gpt":0.2209319015954744,"score_spread":0.2149023146482818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}