{"id":"W2127376694","doi":"10.1074/jbc.c200608200","title":"The N-terminal Truncated Isoform of SOCS3 Translated from an Alternative Initiation AUG Codon under Stress Conditions Is Stable Due to the Lack of a Major Ubiquitination Site, Lys-6","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"SOCS3; Endoplasmic reticulum; Biology; Cell biology; Proteasome; SOCS2; Ubiquitin; Unfolded protein response; Gene isoform; Ubiquitin ligase; Phosphorylation; Molecular biology; Biochemistry; Gene; STAT3; Suppressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003093138,0.0001081965,0.0002752396,0.00006000958,0.0001053178,0.00001797782,0.0001222423,0.0001100889,0.0007122732],"category_scores_gemma":[0.0002763754,0.0000571585,0.0001453988,0.0003033792,0.0001065984,0.00008645264,0.00001006892,0.0002822495,0.000001844851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006307949,"about_ca_system_score_gemma":0.0001079196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006230622,"about_ca_topic_score_gemma":0.00001946606,"domain_scores_codex":[0.9988791,0.00007723155,0.0005795822,0.0001128793,0.0002238553,0.0001273759],"domain_scores_gemma":[0.9983298,0.0003135269,0.0005395691,0.0001365537,0.0005945439,0.00008607387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004283662,0.0003713334,0.001012206,0.00002419742,0.0001587699,0.00001868957,0.0007046035,0.0001170547,0.9964486,0.00009314946,0.000316046,0.0003070083],"study_design_scores_gemma":[0.0009934368,0.000597453,0.01302584,0.0001771983,0.0001191643,0.0001725374,0.001322527,0.0002830053,0.9816858,0.0008850922,0.0006685142,0.00006949402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996482,0.0001096416,0.0008965529,0.001177668,0.00006488066,0.0001267091,0.0004759157,0.000006180454,0.0006604521],"genre_scores_gemma":[0.9992428,0.00003784633,0.0001323858,0.000250086,0.0001246737,0.000004617439,0.0001375641,0.000006408128,0.00006358125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01476284,"threshold_uncertainty_score":0.7798892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06539462007891825,"score_gpt":0.3450462132375835,"score_spread":0.2796515931586653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}