{"id":"W2127462363","doi":"10.1124/dmd.111.039115","title":"Effects of Chronic Renal Failure on Kidney Drug Transporters and Cytochrome P450 in Rats","year":2011,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Kidney; Organic anion transporter 1; Internal medicine; Endocrinology; Organic anion-transporting polypeptide; Renal function; Chemistry; Transporter; Multidrug resistance-associated protein 2; Cytochrome P450; P-glycoprotein; Renal physiology; Pharmacology; Metabolism; Biology; ATP-binding cassette transporter; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005134289,0.0011256,0.001434473,0.001010308,0.0007565251,0.0005186042,0.000513714,0.001010764,0.00257732],"category_scores_gemma":[0.0008392512,0.0006654603,0.001131258,0.0005738575,0.001680103,0.001388604,0.0004764954,0.002338807,0.0004147006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008154211,"about_ca_system_score_gemma":0.00102793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005342166,"about_ca_topic_score_gemma":0.004982017,"domain_scores_codex":[0.9995819,0.0000624254,0.00002714455,0.00008046946,0.000053021,0.0001950475],"domain_scores_gemma":[0.9984079,0.0004059356,0.0002418742,0.0002643405,0.0001410274,0.0005389224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3499283,0.0118726,0.01608818,0.0003722198,0.0004667595,0.001767021,0.0005613021,0.002603305,0.5878036,0.0008897259,0.001119783,0.02652727],"study_design_scores_gemma":[0.004423515,0.07793632,0.07065792,0.00005061061,0.001041507,0.001127961,0.000986216,0.008413508,0.8304049,0.001269611,0.003430793,0.0002571528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982432,0.0005118909,0.000348321,0.0001561868,0.00006118266,0.00002078277,0.0003149608,0.00004449415,0.0002988765],"genre_scores_gemma":[0.9954305,0.0007403673,0.0004614028,0.0001339099,0.00006526131,0.00004383564,0.0005154381,0.00003333574,0.002576001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005342166,"threshold_uncertainty_score":0.01062214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004459732465642279,"score_gpt":0.1971889257720271,"score_spread":0.1927291933063848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}