{"id":"W2127462363","doi":"10.1124/dmd.111.039115","title":"Effects of Chronic Renal Failure on Kidney Drug Transporters and Cytochrome P450 in Rats","year":2011,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Kidney; Organic anion transporter 1; Internal medicine; Endocrinology; Organic anion-transporting polypeptide; Renal function; Chemistry; Transporter; Multidrug resistance-associated protein 2; Cytochrome P450; P-glycoprotein; Renal physiology; Pharmacology; Metabolism; Biology; ATP-binding cassette transporter; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572904,0.0002001049,0.0004342138,0.0002024926,0.00004887734,0.000007121836,0.00004608445,0.00008187133,0.00003404745],"category_scores_gemma":[0.000004825733,0.0001591815,0.00007799784,0.0001598343,0.000103892,0.0001406373,0.000005911816,0.0001589773,0.000002357228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001828546,"about_ca_system_score_gemma":0.0000536915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008879767,"about_ca_topic_score_gemma":0.00009244688,"domain_scores_codex":[0.9989578,0.00004125709,0.0002714528,0.0003019602,0.0002025319,0.0002249791],"domain_scores_gemma":[0.9995148,0.00002015571,0.00007352229,0.0001446871,0.00002643674,0.0002204297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001325797,0.0005762579,0.000628079,0.001614955,0.00007359755,0.0002351226,0.006312854,0.000001288816,0.9781883,0.00680097,0.0001945866,0.004048138],"study_design_scores_gemma":[0.004785018,0.0001599393,0.6180385,0.001113514,0.0004515789,0.00001641886,0.0002046518,0.00003104348,0.373511,0.0006955098,0.0007570233,0.0002357689],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960711,0.002208436,0.0002784689,0.0003012953,0.00007879948,0.0005322239,0.00003167535,0.00002998649,0.0004679872],"genre_scores_gemma":[0.9983671,0.0006268506,0.0003404905,0.0002650608,0.00008484135,0.00003286642,0.00009396059,0.00002063649,0.0001681589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6174105,"threshold_uncertainty_score":0.6491232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004459732465642279,"score_gpt":0.1971889257720271,"score_spread":0.1927291933063848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}