{"id":"W2127486186","doi":"10.1002/anie.201303225","title":"Rapid, Isothermal DNA Self‐Replication Induced by a Destabilizing Lesion","year":2013,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Loop-mediated isothermal amplification; Replication (statistics); DNA ligase; DNA replication; Isothermal process; Computer science; Ligation; Computational biology; DNA; Chemistry; Biology; Molecular biology; Physics; Biochemistry; Thermodynamics; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003990894,0.0003816927,0.0002701627,0.0002233133,0.0001667987,0.0003837936,0.0003747997,0.0004808898,0.00170185],"category_scores_gemma":[0.0005463067,0.0003489279,0.0003137313,0.0001118485,0.0003399664,0.0003594103,0.0003521881,0.0008114305,0.001139098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002435333,"about_ca_system_score_gemma":0.0004208275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002674642,"about_ca_topic_score_gemma":0.0004018645,"domain_scores_codex":[0.9996904,0.0000390792,0.0000186621,0.0001092122,0.00009250915,0.00005016711],"domain_scores_gemma":[0.9996545,0.0000767676,0.0000943299,0.00007488164,0.00005731735,0.00004216638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004501432,0.00001616957,0.0000663242,0.00002983303,0.000003477272,0.00003823698,0.00002671534,0.0000627058,0.9966838,0.0002679409,0.00009072856,0.002669102],"study_design_scores_gemma":[0.00000453511,0.00006559324,0.0001126841,0.000001799895,0.0000028552,0.00005773609,0.000003012628,0.0003912104,0.9982299,0.00002393728,0.001102865,0.000003884409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8773442,0.001282897,0.1112016,0.0004301553,0.0002244089,0.000270073,0.000442584,0.001791821,0.007012139],"genre_scores_gemma":[0.9512309,0.000439874,0.03580869,0.0001232749,0.00002610325,0.0001150489,0.0004940147,0.0001812875,0.01158072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170185,"threshold_uncertainty_score":0.005693316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572145696194141,"score_gpt":0.275277409347778,"score_spread":0.2595559523858366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}