{"id":"W2127487757","doi":"10.1038/gt.2011.25","title":"Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Gene delivery; Genetic enhancement; Furin; Plasmid; Chitosan; Enhancer; Glucagon-like peptide-1; Dipeptidyl peptidase; Biology; Pharmacology; Diabetes mellitus; Type 2 diabetes; Gene; Endocrinology; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460692,0.0001631125,0.0004304966,0.0001705653,0.00002942456,0.000003723865,0.00006192303,0.00008163809,0.00005930082],"category_scores_gemma":[0.00001090724,0.0001337805,0.00005986096,0.000178263,0.000137985,0.00006710812,0.00001238607,0.00006623477,8.15311e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001822336,"about_ca_system_score_gemma":0.0001057721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006948944,"about_ca_topic_score_gemma":0.000003562182,"domain_scores_codex":[0.9991072,0.00009710118,0.0002501256,0.000211367,0.0001374712,0.00019672],"domain_scores_gemma":[0.9994332,0.00008107857,0.0001083631,0.0002242229,0.0000774466,0.00007572654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00167047,0.0002567035,0.1282468,0.00004583664,0.00009047508,8.584706e-7,0.0005611205,0.0001915602,0.8654045,0.00001959231,0.000001167249,0.003510837],"study_design_scores_gemma":[0.002501074,0.00163338,0.1239797,0.00005103893,0.0000518562,0.000001096357,0.00004332606,0.04757479,0.8238688,0.000187263,0.000001980921,0.0001057574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967426,0.002484735,0.00009757974,0.00001163404,0.00004793646,0.0004195724,0.00001562713,0.00002008007,0.0001602519],"genre_scores_gemma":[0.9942352,0.0001704933,0.005185733,0.0003251766,0.00003112215,0.00001317163,0.00001154027,0.00002417575,0.000003381499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04738323,"threshold_uncertainty_score":0.5455411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0657103946566432,"score_gpt":0.2747786274864887,"score_spread":0.2090682328298455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}