{"id":"W2127487757","doi":"10.1038/gt.2011.25","title":"Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Gene delivery; Genetic enhancement; Furin; Plasmid; Chitosan; Enhancer; Glucagon-like peptide-1; Dipeptidyl peptidase; Biology; Pharmacology; Diabetes mellitus; Type 2 diabetes; Gene; Endocrinology; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005007694,0.0005484382,0.0006153701,0.0005752128,0.0002438831,0.0005275076,0.0005694292,0.0009426277,0.0007417974],"category_scores_gemma":[0.0003057577,0.0003682175,0.0003980247,0.0002635133,0.0007583058,0.0006522434,0.0002764392,0.001276626,0.0001657912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007510183,"about_ca_system_score_gemma":0.000613125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001773448,"about_ca_topic_score_gemma":0.001538761,"domain_scores_codex":[0.9996374,0.00005903234,0.00002605601,0.00007858523,0.0001156509,0.00008313841],"domain_scores_gemma":[0.999736,0.00005161062,0.00008859931,0.0000277686,0.00003137192,0.00006474014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002711656,0.0000776544,0.0000265225,0.0000376565,0.00000709417,0.00005505104,0.00002326854,0.000164474,0.9980919,0.0001309526,0.00003689247,0.001077291],"study_design_scores_gemma":[0.00004849958,0.0004517777,0.0001558052,0.000003628543,0.00002318573,0.0000571493,0.000008651012,0.0006925216,0.9978269,0.00002359694,0.0007003919,0.00000779312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861385,0.001442899,0.01020088,0.0003635123,0.0001338873,0.0001235463,0.0002096849,0.0002133316,0.001173631],"genre_scores_gemma":[0.9876701,0.001085444,0.007712802,0.00008421877,0.00002700587,0.00009011999,0.0001830767,0.00007474074,0.003072561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001773448,"threshold_uncertainty_score":0.005449057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0657103946566432,"score_gpt":0.2747786274864887,"score_spread":0.2090682328298455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}