{"id":"W2127513830","doi":"10.1124/mol.60.1.42","title":"Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Secretoneurin Release and Secretogranin II Gene Transcription in Bovine Adrenochromaffin Cells through Multiple Signaling Pathways and Increased Binding of Pre-Existing Activator Protein-1-Like Transcription Factors","year":2001,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Pituitary adenylate cyclase-activating peptide; Protein kinase C; Activator (genetics); Protein kinase A; Internal medicine; Endocrinology; Adenylate kinase; Biology; Forskolin; Signal transduction; Chemistry; Molecular biology; Neuropeptide; Kinase; Cell biology; Receptor; Vasoactive intestinal peptide; Biochemistry; Stimulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002794506,0.0005081948,0.0006070643,0.0005568117,0.0004418883,0.000747729,0.0003092749,0.0003904279,0.001844622],"category_scores_gemma":[0.0004605124,0.0004395321,0.0007024529,0.0003928416,0.0007522725,0.0005933549,0.0005759436,0.001253205,0.0004475022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001821312,"about_ca_system_score_gemma":0.0005656306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005495409,"about_ca_topic_score_gemma":0.00997875,"domain_scores_codex":[0.9995537,0.00004504533,0.00002881202,0.0001040266,0.00009358147,0.0001747887],"domain_scores_gemma":[0.9994158,0.0001994224,0.0000629635,0.00006406668,0.00003784905,0.0002199955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003787134,0.00002360316,0.0001590225,0.00002238838,0.000004118028,0.00005593817,0.00002488665,0.00001621864,0.9988096,0.00006628071,0.00002771938,0.0004115208],"study_design_scores_gemma":[0.00009191324,0.0004161654,0.02074605,0.00001344733,0.0000352694,0.000243408,0.0001353668,0.0008026665,0.9757363,0.0001649866,0.001599447,0.0000150144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886997,0.006004429,0.002249457,0.0003184678,0.0001908773,0.00003681104,0.0005149848,0.00008848744,0.001896797],"genre_scores_gemma":[0.9926846,0.001437662,0.001568767,0.0001832222,0.0001052739,0.00004073188,0.001050879,0.00005331522,0.002875477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005495409,"threshold_uncertainty_score":0.01321459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03387376099928584,"score_gpt":0.2635423491215724,"score_spread":0.2296685881222866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}