{"id":"W2127513830","doi":"10.1124/mol.60.1.42","title":"Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Secretoneurin Release and Secretogranin II Gene Transcription in Bovine Adrenochromaffin Cells through Multiple Signaling Pathways and Increased Binding of Pre-Existing Activator Protein-1-Like Transcription Factors","year":2001,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Pituitary adenylate cyclase-activating peptide; Protein kinase C; Activator (genetics); Protein kinase A; Internal medicine; Endocrinology; Adenylate kinase; Biology; Forskolin; Signal transduction; Chemistry; Molecular biology; Neuropeptide; Kinase; Cell biology; Receptor; Vasoactive intestinal peptide; Biochemistry; Stimulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001724819,0.0004428312,0.0005522337,0.000249988,0.0003436734,0.00003147836,0.0001922919,0.0001707276,0.00005917167],"category_scores_gemma":[0.0001273898,0.0004594799,0.0001095962,0.0004440456,0.0002728305,0.0004312208,0.0001180224,0.0005246914,0.000001152714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005602392,"about_ca_system_score_gemma":0.00004783427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005405711,"about_ca_topic_score_gemma":0.0000124682,"domain_scores_codex":[0.9969606,0.0006267964,0.000640114,0.0009170433,0.0002215894,0.0006338413],"domain_scores_gemma":[0.9990155,0.0002935484,0.0003156533,0.0001588366,0.00003833609,0.0001781603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001385098,0.0002488034,0.0007193824,0.0001508494,0.00002556324,0.0003857296,0.001215408,0.001166529,0.99419,0.00002972426,0.000002085373,0.0004808393],"study_design_scores_gemma":[0.002705679,0.000987343,0.002691703,0.0001147519,0.00005183406,0.00005872592,0.0001308037,0.007181891,0.9855273,0.00009077452,0.00006401245,0.0003951327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979973,0.00018493,0.0004119513,0.00003298953,0.0001224133,0.001012907,0.0001005163,0.0001086921,0.00002834236],"genre_scores_gemma":[0.9985326,0.0001008225,0.0008066936,0.0003221601,0.00005520608,0.00004994776,0.00003867452,0.00008062395,0.00001327552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00866264,"threshold_uncertainty_score":0.9997857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03387376099928584,"score_gpt":0.2635423491215724,"score_spread":0.2296685881222866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}