{"id":"W2127570377","doi":"10.1093/toxsci/kfm035","title":"Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Medicinal Plant Extracts Effects","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institutes of Health","keywords":"Kava; Oxidative stress; Lipid peroxidation; Malondialdehyde; Chemistry; Pharmacology; Toxicity; Glutathione; Superoxide dismutase; Cytochrome P450; Liver injury; CYP2E1; Biochemistry; Biology; Metabolism","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001592932,0.000182554,0.000482554,0.0002274148,0.00008125533,0.00001636357,0.0001131852,0.0001505021,0.00004005728],"category_scores_gemma":[0.002107355,0.0001089951,0.00002565717,0.0004680995,0.001106327,0.0001013772,0.00006526063,0.0002668219,0.000004974567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003344455,"about_ca_system_score_gemma":0.00004603316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005568404,"about_ca_topic_score_gemma":0.00005084852,"domain_scores_codex":[0.9982424,0.000140006,0.000290417,0.0004371317,0.000485404,0.0004046828],"domain_scores_gemma":[0.995538,0.003961969,0.0001188399,0.00008863856,0.00003206512,0.0002604898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004256832,0.0004564762,0.03030939,0.0002960718,0.000009991928,0.0005186816,0.0002841637,0.000004288214,0.9593331,0.0007527289,0.00003011822,0.007579282],"study_design_scores_gemma":[0.0008447489,0.004917798,0.7265978,0.0004301089,0.00002238488,0.0000600126,0.0001794808,0.00007297038,0.2665469,0.0002083937,0.00001845349,0.0001010007],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943328,0.0005739707,0.00003605235,0.00036965,0.0000506953,0.0006847051,0.000003033242,0.00002716667,0.003921851],"genre_scores_gemma":[0.9987001,0.0001109501,0.0006167266,0.0004246367,0.00005946191,0.00000918972,0.00000177648,0.000004398145,0.00007280347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6962883,"threshold_uncertainty_score":0.4444691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175869370468905,"score_gpt":0.3198652474583258,"score_spread":0.2981065537536367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}