{"id":"W2127578681","doi":"10.1016/j.bmc.2010.09.059","title":"Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo; University of Toronto; Ontario Institute for Cancer Research; Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Stereochemistry; Sulfonium; Enzyme; Maltase; Moiety; Active site; Hydrolase; Acarbose; Ring (chemistry); Biochemistry; Salt (chemistry); Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330781,0.000155876,0.0002148195,0.00003374555,0.00007132914,0.000005833781,0.0001140267,0.0001331634,0.00003952927],"category_scores_gemma":[0.0003379639,0.00013249,0.00003417703,0.00009621486,0.0003472567,0.00001129189,0.0001118753,0.0001722388,1.110392e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001377889,"about_ca_system_score_gemma":0.0000988618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001493475,"about_ca_topic_score_gemma":0.000007178388,"domain_scores_codex":[0.9990956,0.00004423424,0.0003044974,0.0002521846,0.0001552091,0.0001482445],"domain_scores_gemma":[0.999209,0.00003817734,0.0003722469,0.0001786912,0.0001380256,0.00006382068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013777,0.00006373844,0.005449831,0.0003765119,0.00007202304,0.000002480952,0.000367874,2.447044e-7,0.9931198,0.000006221181,0.00001270205,0.0003908256],"study_design_scores_gemma":[0.0003836403,0.0001091988,0.006618617,0.0001758179,0.00007317298,0.0001470451,0.0006234818,0.00002793233,0.9916998,0.000009997361,0.00002114924,0.0001101291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994046,0.0002365321,0.00001528544,0.00006227661,0.0000295985,0.0001227353,0.0000534238,0.000006957983,0.00006859108],"genre_scores_gemma":[0.9996088,0.00004183513,0.00005513115,0.00001430034,0.0001517497,0.000009577894,0.00006942551,0.0000164129,0.00003273315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419958,"threshold_uncertainty_score":0.5402785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208862152985019,"score_gpt":0.2450778292918177,"score_spread":0.2329892077619675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}