{"id":"W2127578681","doi":"10.1016/j.bmc.2010.09.059","title":"Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo; University of Toronto; Ontario Institute for Cancer Research; Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Stereochemistry; Sulfonium; Enzyme; Maltase; Moiety; Active site; Hydrolase; Acarbose; Ring (chemistry); Biochemistry; Salt (chemistry); Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153765,0.0001844686,0.0001673555,0.00006171189,0.00005597223,0.0001527295,0.0001944001,0.0001751031,0.0004801425],"category_scores_gemma":[0.0001965412,0.00008539462,0.00009267795,0.00008844399,0.0001481636,0.0001544072,0.00008060764,0.0002490959,0.0001559395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249112,"about_ca_system_score_gemma":0.000158679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005251829,"about_ca_topic_score_gemma":0.0007959036,"domain_scores_codex":[0.9999276,0.0000198313,0.000007877161,0.0000127177,0.00001866989,0.00001323788],"domain_scores_gemma":[0.9999299,0.00002327376,0.00001677109,0.000007355422,0.000008303028,0.0000143522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001484435,0.00001177031,0.0001117725,0.00001332536,0.000001689703,0.00002334169,0.000007345211,0.0001077582,0.9989731,0.00004347814,0.000005960133,0.0005520185],"study_design_scores_gemma":[0.00001086154,0.0001692316,0.0007497517,8.080524e-7,0.000004457141,0.0001178715,0.00000745348,0.0004577283,0.9981344,0.00001320364,0.0003323302,0.000001912023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980302,0.0004218128,0.001111243,0.00002851172,0.000003631083,0.00000846185,0.00009249875,0.00001050593,0.0002930535],"genre_scores_gemma":[0.9978255,0.0003109748,0.001232143,0.00001368422,0.00000291047,0.000006381001,0.000257286,0.000005223331,0.0003459956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005251829,"threshold_uncertainty_score":0.001631916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208862152985019,"score_gpt":0.2450778292918177,"score_spread":0.2329892077619675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}