{"id":"W2127586500","doi":"10.4049/jimmunol.0904060","title":"MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":558,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Chinese Academy of Sciences","keywords":"DNMT1; DNA methylation; DNA methyltransferase; microRNA; Biology; Systemic lupus erythematosus; Epigenetics; Methylation; Cancer research; Regulation of gene expression; Methyltransferase; Lupus erythematosus; Gene expression; Molecular biology; Immunology; Gene; Genetics; Disease; Antibody; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001448341,0.0002888294,0.000355902,0.0002725498,0.0001976486,0.0003457596,0.000159138,0.000322454,0.001199089],"category_scores_gemma":[0.0001936335,0.0002192099,0.0003455311,0.0001212205,0.0001827584,0.0001209759,0.0002287301,0.0005231151,0.0003088526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002644589,"about_ca_system_score_gemma":0.0002525031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918048,"about_ca_topic_score_gemma":0.000305542,"domain_scores_codex":[0.9997576,0.00004075184,0.00002868995,0.0000657148,0.00005793529,0.00004933654],"domain_scores_gemma":[0.9999088,0.00001022272,0.00003553979,0.000007872792,0.00001060078,0.00002699224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001749258,0.00002231421,0.001175443,0.00003778301,0.00001157802,0.00007936978,0.00002007755,0.00006119782,0.996415,0.00006595705,0.00004694895,0.001889352],"study_design_scores_gemma":[0.0001008519,0.0006582924,0.03977111,0.00001345399,0.00009477282,0.001457418,0.00005172703,0.002454377,0.9502923,0.0001878665,0.004904613,0.0000131081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922356,0.003125876,0.00278814,0.0001456605,0.00003803306,0.00003306589,0.0002168382,0.0001129879,0.001303678],"genre_scores_gemma":[0.9955038,0.0006648097,0.002365536,0.0001022381,0.00001611724,0.00004960598,0.0002244087,0.00001575242,0.001057773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199089,"threshold_uncertainty_score":0.004011393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004029368273045768,"score_gpt":0.2185922635993921,"score_spread":0.2145628953263463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}