{"id":"W2127621744","doi":"10.1161/atvbaha.114.303252","title":"Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine <i>N</i> -Oxide, a Proatherogenic Metabolite of Choline and <scp>l</scp> -Carnitine","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Trimethylamine N-oxide; Biology; Locus (genetics); Quantitative trait locus; Genome-wide association study; Genetics; Carnitine; Genetic association; Choline; Expression quantitative trait loci; Gene; Genotyping; Single-nucleotide polymorphism; Trimethylamine; Genotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001444467,0.0006423028,0.0005293609,0.001332381,0.0005550578,0.0005982675,0.0005508295,0.0009904419,0.003179588],"category_scores_gemma":[0.001862902,0.0003745851,0.000964572,0.0014954,0.0005645977,0.0001932504,0.0006075146,0.0008411286,0.0002108764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913395,"about_ca_system_score_gemma":0.0002600989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002891255,"about_ca_topic_score_gemma":0.003701929,"domain_scores_codex":[0.9986004,0.000355948,0.00008962551,0.0007326456,0.0001231849,0.00009808997],"domain_scores_gemma":[0.9982499,0.0007756784,0.0005034965,0.0001872083,0.00009635534,0.0001872322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006038128,0.0001735396,0.8442538,0.0002806862,0.005283671,0.001536777,0.0005517693,0.0004834403,0.1274255,0.0008742652,0.0008727132,0.01222575],"study_design_scores_gemma":[0.0002055602,0.0004957473,0.9897026,0.00003755687,0.001440032,0.002634508,0.0001459558,0.0005268247,0.002873455,0.000343666,0.001574223,0.00001995523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939213,0.00169823,0.002112256,0.0001894543,0.00001891927,0.0000234297,0.001246354,0.00004656922,0.0007435189],"genre_scores_gemma":[0.9937378,0.0006267679,0.00336798,0.0001478435,0.00002196553,0.00008250498,0.001517302,0.00002899314,0.0004688438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003179588,"threshold_uncertainty_score":0.01063675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0398381128564554,"score_gpt":0.3057680572315035,"score_spread":0.2659299443750481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}