{"id":"W2127621744","doi":"10.1161/atvbaha.114.303252","title":"Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine <i>N</i> -Oxide, a Proatherogenic Metabolite of Choline and <scp>l</scp> -Carnitine","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Trimethylamine N-oxide; Biology; Locus (genetics); Quantitative trait locus; Genome-wide association study; Genetics; Carnitine; Genetic association; Choline; Expression quantitative trait loci; Gene; Genotyping; Single-nucleotide polymorphism; Trimethylamine; Genotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008124955,0.0002343829,0.0007141524,0.00008414141,0.00008492255,0.00001710486,0.00008926162,0.0001770943,8.957349e-7],"category_scores_gemma":[0.0005682505,0.0002061475,0.0001023852,0.00009532068,0.0002496824,0.000008826606,0.0001185327,0.00006322133,4.049353e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004337241,"about_ca_system_score_gemma":0.00001397091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002451697,"about_ca_topic_score_gemma":0.00009727701,"domain_scores_codex":[0.9984883,0.0002664364,0.0003949371,0.0004913416,0.00006731333,0.000291639],"domain_scores_gemma":[0.9990615,0.0003285188,0.0002247886,0.0001880763,0.0001324787,0.00006458724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000005815764,0.00009450923,0.2150901,0.00009051363,0.0005697227,4.096639e-9,0.0009571514,0.000003536551,0.782705,0.0001222259,0.00009329172,0.0002681713],"study_design_scores_gemma":[0.002549506,0.0004658211,0.9511868,0.00002108979,0.0002253464,1.779041e-7,0.0007934902,0.00003770872,0.02244648,0.0002262563,0.02190862,0.0001387426],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892197,0.009507659,0.0005379955,0.0001030063,0.00005223665,0.000473275,0.00006310001,0.000005957998,0.00003711603],"genre_scores_gemma":[0.9714315,0.02663888,0.001178466,0.0004155848,0.00006107155,0.0001111191,0.0001212078,0.00001780698,0.00002435468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7602585,"threshold_uncertainty_score":0.840645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0398381128564554,"score_gpt":0.3057680572315035,"score_spread":0.2659299443750481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}