{"id":"W2127647970","doi":"10.1161/atvbaha.115.305513","title":"Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease","year":2015,"lang":"en","type":"review","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute on Minority Health and Health Disparities; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Wellcome Trust","keywords":"Genome-wide association study; Biology; Genetic association; Coronary artery disease; Genetics; Computational biology; Gene regulatory network; KEGG; Biological pathway; Systems biology; Gene; Biological network; Bioinformatics; Single-nucleotide polymorphism; Medicine; Internal medicine; Transcriptome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003467624,0.0006882961,0.0007065312,0.002518406,0.0004539255,0.001328162,0.0004689874,0.0004339667,0.001898956],"category_scores_gemma":[0.005648935,0.0003246395,0.001805426,0.002453467,0.0007063464,0.0004144351,0.0008410969,0.0005239812,0.0001566132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005871075,"about_ca_system_score_gemma":0.00111766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00217328,"about_ca_topic_score_gemma":0.002965592,"domain_scores_codex":[0.9973541,0.001380516,0.0001182507,0.0008372157,0.0002128701,0.00009704316],"domain_scores_gemma":[0.996947,0.001999537,0.0005671522,0.0002746976,0.0001292184,0.00008248883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007535047,0.0001571491,0.8662277,0.00081775,0.01144543,0.001144932,0.0003842397,0.01584061,0.06206683,0.007258678,0.001323911,0.03257922],"study_design_scores_gemma":[0.0001570483,0.0003605481,0.8968532,0.00007837045,0.004341431,0.0007172919,0.0002046158,0.06795913,0.004768457,0.02247745,0.00202388,0.00005860999],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9195756,0.003770176,0.07043806,0.0008754752,0.00006656864,0.0001056576,0.002767354,0.0005899241,0.001811197],"genre_scores_gemma":[0.9854512,0.0005751468,0.01274404,0.0001146877,0.00002169086,0.0000655201,0.000813601,0.00002833577,0.0001856814],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003467624,"threshold_uncertainty_score":0.01833874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1119631803914373,"score_gpt":0.3446365253161853,"score_spread":0.232673344924748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}