{"id":"W2127666874","doi":"10.1128/mcb.00825-13","title":"Grb2 Promotes Integrin-Induced Focal Adhesion Kinase (FAK) Autophosphorylation and Directs the Phosphorylation of Protein Tyrosine Phosphatase α by the Src-FAK Kinase Complex","year":2013,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Child and Family Research Institute","keywords":"Paxillin; Focal adhesion; GRB2; Proto-oncogene tyrosine-protein kinase Src; Autophosphorylation; Phosphorylation; Cell biology; PTK2; Tyrosine phosphorylation; Integrin; Biology; Signal transducing adaptor protein; Protein tyrosine phosphatase; SH2 domain; Signal transduction; Protein kinase A; Biochemistry; Receptor; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129022,0.000546083,0.0002491959,0.0002962874,0.0001902888,0.0003246168,0.000178007,0.0002499562,0.001957107],"category_scores_gemma":[0.00007274,0.0001697686,0.0003930851,0.000240897,0.0001173321,0.0001986676,0.0003703877,0.0005419336,0.0005681333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271589,"about_ca_system_score_gemma":0.0001577392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006377696,"about_ca_topic_score_gemma":0.001189886,"domain_scores_codex":[0.9998592,0.00001548347,0.00001183192,0.00002337709,0.00005159768,0.00003847777],"domain_scores_gemma":[0.9999517,0.000005915616,0.00001311545,0.000007008954,0.000005666543,0.00001648046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001577175,0.00008492714,0.0004294636,0.00008634891,0.00001498205,0.0001714731,0.00001462252,0.00009635195,0.9958967,0.000144116,0.0002159737,0.002687459],"study_design_scores_gemma":[0.00006509307,0.000434659,0.0200166,0.00001405502,0.00003201704,0.0008632136,0.00003092695,0.001774851,0.9679529,0.00009637497,0.008709839,0.00000957852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860533,0.005604418,0.003572799,0.0001931374,0.00009660261,0.00004837422,0.0004441217,0.0002019745,0.00378524],"genre_scores_gemma":[0.9894301,0.002422903,0.001464342,0.00007433385,0.00002685552,0.00004804075,0.0008620957,0.00001792394,0.005653484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001957107,"threshold_uncertainty_score":0.006547213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0173867287685251,"score_gpt":0.2620507597335717,"score_spread":0.2446640309650466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}