{"id":"W2127682944","doi":"10.1124/dmd.105.005546","title":"METABOLISM OF THE ONE-RING OPEN METABOLITES OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE TO ITS ACTIVE METAL-CHELATING FORM IN THE RAT","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Chemistry; Metabolite; Metabolism; Pharmacology; Pharmacokinetics; In vivo; Chelation; Biochemistry; Internal medicine; Biology; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001215084,0.0002430476,0.0007098949,0.000130799,0.0002461816,0.00004787301,0.0004067352,0.00008919485,0.00001117817],"category_scores_gemma":[0.0001981816,0.0001347897,0.0003256539,0.0007931508,0.0001134371,0.0005508369,0.0002314172,0.0003753384,0.000001657926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005222236,"about_ca_system_score_gemma":0.0000842882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005507967,"about_ca_topic_score_gemma":0.0002141314,"domain_scores_codex":[0.9979407,0.0004131685,0.000485858,0.0003319276,0.0005641031,0.0002642196],"domain_scores_gemma":[0.9987445,0.0001423875,0.0003047228,0.0005379381,0.0001980131,0.00007241071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000323097,0.0001851441,0.0002543496,0.00008677421,0.0002740811,6.14291e-7,0.0296815,0.0001582247,0.9324257,0.01064405,0.00002056409,0.02594585],"study_design_scores_gemma":[0.001512399,0.00001104671,0.148302,0.0001766234,0.0006577718,0.00001678586,0.002955582,0.00006981,0.84434,0.0008723215,0.0009547755,0.0001308706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884778,0.002890377,0.0000837827,0.003276632,0.0001772182,0.002620862,0.00006111536,0.00001236472,0.002399859],"genre_scores_gemma":[0.9978001,0.0001494559,0.000410244,0.0009474697,0.0002712722,0.0001851968,0.00001171363,0.00002385931,0.0002007194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1480477,"threshold_uncertainty_score":0.5496565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01446567493311762,"score_gpt":0.2636349690235162,"score_spread":0.2491692940903986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}