{"id":"W2127682944","doi":"10.1124/dmd.105.005546","title":"METABOLISM OF THE ONE-RING OPEN METABOLITES OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE TO ITS ACTIVE METAL-CHELATING FORM IN THE RAT","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Chemistry; Metabolite; Metabolism; Pharmacology; Pharmacokinetics; In vivo; Chelation; Biochemistry; Internal medicine; Biology; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001924892,0.000686934,0.000472035,0.0006558604,0.0003756144,0.0004231762,0.0003841549,0.000516288,0.00208546],"category_scores_gemma":[0.000297318,0.0004789054,0.0005354025,0.000353035,0.000639193,0.0006337071,0.0001601689,0.0008539399,0.0005082124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000562076,"about_ca_system_score_gemma":0.0005831643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003874062,"about_ca_topic_score_gemma":0.003415299,"domain_scores_codex":[0.9998636,0.00002564404,0.000007420181,0.00004376824,0.00001576271,0.00004383307],"domain_scores_gemma":[0.9996899,0.00004106124,0.00009789684,0.00006544006,0.00002731103,0.00007847808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03641143,0.0009302782,0.003536849,0.0001352403,0.0001103368,0.0004089067,0.000266103,0.0009357759,0.9375814,0.0006736385,0.0003268589,0.01868321],"study_design_scores_gemma":[0.0003675637,0.009550317,0.01154104,0.00001280169,0.0002071859,0.0004792797,0.0001845871,0.002166976,0.9729028,0.000282213,0.002259843,0.00004551973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964605,0.001109274,0.001254335,0.00006750301,0.00003469922,0.00001993517,0.0003793335,0.00005908507,0.0006153669],"genre_scores_gemma":[0.9940922,0.00125882,0.0009217957,0.00004543171,0.00001991702,0.00002316611,0.0005964731,0.00002920176,0.003013033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003874062,"threshold_uncertainty_score":0.007703006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01446567493311762,"score_gpt":0.2636349690235162,"score_spread":0.2491692940903986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}