{"id":"W2127691142","doi":"10.1515/bc.2006.132","title":"Single-cell resolution imaging of membrane-anchored hepatitis C virus NS3/4A protease activity","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"","keywords":"NS3; NS2-3 protease; Endoplasmic reticulum; Proteases; Hepatitis C virus; Protease; Chemistry; Green fluorescent protein; Cleavage (geology); Serine protease; NS5A; Immunofluorescence; Biochemistry; Molecular biology; Virology; Biology; Virus; Hepacivirus; Enzyme; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130027,0.0001401124,0.0002157165,0.0001016375,0.0001308396,0.0003116418,0.0001951723,0.0003813855,0.0008713703],"category_scores_gemma":[0.00009354675,0.0001120687,0.0001125646,0.00008179607,0.0001571305,0.000227354,0.0001632387,0.0003753087,0.0004027211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002444224,"about_ca_system_score_gemma":0.0001376834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005181629,"about_ca_topic_score_gemma":0.0007850931,"domain_scores_codex":[0.9999523,0.000006942188,0.000002771152,0.00001367617,0.00001533231,0.000008955373],"domain_scores_gemma":[0.9999398,0.00002449604,0.000008358278,0.000005929699,0.000009545117,0.00001183814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001579533,0.000004942484,0.00005005012,0.00001060156,0.000001042215,0.00001918302,0.000005419386,0.00006307908,0.9991548,0.00006470633,0.00002756352,0.0005827181],"study_design_scores_gemma":[0.000007215064,0.00004862175,0.00112945,0.000001734809,0.000003873605,0.0001536556,0.00002193913,0.005481428,0.9919368,0.0000814011,0.00113013,0.000003788625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9500908,0.001587175,0.04457016,0.0002020117,0.00003778925,0.00003276193,0.0004552079,0.0002232599,0.002800841],"genre_scores_gemma":[0.9482931,0.001428628,0.04596721,0.00007307783,0.00001563986,0.00006451175,0.0003160075,0.00003179909,0.003810041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008713703,"threshold_uncertainty_score":0.002914965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03791779628739972,"score_gpt":0.2817674923871111,"score_spread":0.2438496960997114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}