{"id":"W2127691142","doi":"10.1515/bc.2006.132","title":"Single-cell resolution imaging of membrane-anchored hepatitis C virus NS3/4A protease activity","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"","keywords":"NS3; NS2-3 protease; Endoplasmic reticulum; Proteases; Hepatitis C virus; Protease; Chemistry; Green fluorescent protein; Cleavage (geology); Serine protease; NS5A; Immunofluorescence; Biochemistry; Molecular biology; Virology; Biology; Virus; Hepacivirus; Enzyme; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002625551,0.0001887194,0.0003602179,0.00003318862,0.00006596991,0.00001500627,0.000140902,0.0002335645,0.0006059753],"category_scores_gemma":[0.000549487,0.0001525914,0.0001425369,0.0002026316,0.0003048629,0.00005368105,0.0001022163,0.0003483808,0.00003095507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001924659,"about_ca_system_score_gemma":0.00009914742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001877062,"about_ca_topic_score_gemma":0.00002156653,"domain_scores_codex":[0.9983832,0.00008348119,0.0003509208,0.0004190264,0.0003525548,0.0004107918],"domain_scores_gemma":[0.9990899,0.0000954287,0.0001414277,0.0003556212,0.0001490288,0.0001685767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000246451,0.0005824986,0.1270493,0.0001992299,0.000008178484,0.00008191348,0.000004817725,0.000001627614,0.8676292,0.000003009383,0.0005502045,0.003643588],"study_design_scores_gemma":[0.0008131419,0.0001165107,0.03902048,0.00005998757,0.00001518174,0.00001506942,0.000004100515,0.0004420902,0.9554636,0.00005406929,0.003841772,0.0001540203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727364,0.0003207239,0.0001720607,0.0002355727,0.00002312719,0.0003805499,0.00008564437,0.0001032747,0.02594262],"genre_scores_gemma":[0.9980435,0.0001278703,0.0007583823,0.00004439331,0.0002426583,0.0000566677,0.0001218106,0.00001717078,0.0005875499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08802883,"threshold_uncertainty_score":0.6635004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03791779628739972,"score_gpt":0.2817674923871111,"score_spread":0.2438496960997114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}