{"id":"W2127717082","doi":"10.1530/erc-15-0319","title":"Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer","year":2015,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Human Genome Research Institute; Cancer Council Queensland; National Health and Medical Research Council; Medical Research Council; Vincent Fairfax Family Foundation; Cancer Council Victoria; Deutsche Krebshilfe; Norges Forskningsråd; Universitetet i Bergen; Helse Vest; Karolinska Institutet; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Deutsche Gesetzliche Unfallversicherung; Canadian Institutes of Health Research; Cancerfonden; Robert Bosch Stiftung; Agency for Science, Technology and Research; Deutsches Krebsforschungszentrum; Hunter Medical Research Institute; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Roswell Park Cancer Institute; Susan G. Komen; Stockholms Läns Landsting; QIMR Berghofer Medical Research Institute; Mayo Foundation for Medical Education and Research; Francis Crick Institute; Cancer Research UK; Wellcome Trust; Breast Cancer Research Foundation; University of Cambridge; Kreftforeningen; Ovarian Cancer Research Fund; European Commission","keywords":"Single-nucleotide polymorphism; Estrogen receptor alpha; Endometrial cancer; Locus (genetics); SNP; Breast cancer; Estrogen receptor; Biology; Cancer; Oncology; Medicine; Genetics; Gene; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007634964,0.000401893,0.0006119177,0.0009767713,0.0002817054,0.000432407,0.0003348712,0.0004710304,0.00183071],"category_scores_gemma":[0.001943184,0.0002221605,0.0007195522,0.0009947224,0.0002806585,0.0001150641,0.0006529061,0.0003494927,0.0002717077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140095,"about_ca_system_score_gemma":0.0002272959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009330892,"about_ca_topic_score_gemma":0.001426005,"domain_scores_codex":[0.9994503,0.0001570598,0.00004964548,0.0001951952,0.00009844468,0.00004942213],"domain_scores_gemma":[0.9987367,0.0006021773,0.0003026835,0.0001297856,0.00007561193,0.0001531567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002686898,0.0001525257,0.7134148,0.0002272429,0.001314412,0.003505412,0.0004937677,0.00263081,0.2269122,0.0007007134,0.0005675703,0.04739356],"study_design_scores_gemma":[0.0000674769,0.0004393111,0.9854153,0.00002929259,0.0004910255,0.00293938,0.000107237,0.001555436,0.00718577,0.0005253856,0.001219833,0.00002454184],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996166,0.0007586558,0.002004096,0.00005999516,0.000006563655,0.00001433631,0.0005756978,0.00004324607,0.0003714936],"genre_scores_gemma":[0.9964104,0.0002274611,0.002699075,0.00003929273,0.000009845364,0.000008878976,0.0003752886,0.00001085085,0.0002187974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00183071,"threshold_uncertainty_score":0.006124318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028614065841257,"score_gpt":0.324249249533647,"score_spread":0.3039631088752345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}