{"id":"W2127717082","doi":"10.1530/erc-15-0319","title":"Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer","year":2015,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Human Genome Research Institute; Cancer Council Queensland; National Health and Medical Research Council; Medical Research Council; Vincent Fairfax Family Foundation; Cancer Council Victoria; Deutsche Krebshilfe; Norges Forskningsråd; Universitetet i Bergen; Helse Vest; Karolinska Institutet; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Deutsche Gesetzliche Unfallversicherung; Canadian Institutes of Health Research; Cancerfonden; Robert Bosch Stiftung; Agency for Science, Technology and Research; Deutsches Krebsforschungszentrum; Hunter Medical Research Institute; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Roswell Park Cancer Institute; Susan G. Komen; Stockholms Läns Landsting; QIMR Berghofer Medical Research Institute; Mayo Foundation for Medical Education and Research; Francis Crick Institute; Cancer Research UK; Wellcome Trust; Breast Cancer Research Foundation; University of Cambridge; Kreftforeningen; Ovarian Cancer Research Fund; European Commission","keywords":"Single-nucleotide polymorphism; Estrogen receptor alpha; Endometrial cancer; Locus (genetics); SNP; Breast cancer; Estrogen receptor; Biology; Cancer; Oncology; Medicine; Genetics; Gene; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009742111,0.0002009762,0.0002586053,0.00006479819,0.00009788339,0.00001529748,0.0002407363,0.0001538949,0.00001417283],"category_scores_gemma":[0.0001189608,0.0001417655,0.0002432777,0.0002742265,0.0001361003,0.00000502874,0.0001320536,0.0002366295,0.000001816261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008857202,"about_ca_system_score_gemma":0.0003557302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006815114,"about_ca_topic_score_gemma":0.00004692544,"domain_scores_codex":[0.9986347,0.0001637513,0.0003378857,0.0003404943,0.0002243434,0.0002988418],"domain_scores_gemma":[0.9988528,0.00004976232,0.000317773,0.0003906788,0.0002869183,0.0001020581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001775067,0.0003828219,0.09175492,0.0002932793,0.00408945,0.00004525803,0.000412373,0.05412763,0.7535682,0.000339828,0.0635187,0.02969249],"study_design_scores_gemma":[0.01703823,0.001394769,0.01701413,0.0002420652,0.001134247,0.000143767,0.0002277236,0.00222465,0.8229987,0.0007202795,0.1360766,0.0007849102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649715,0.0313446,0.0003887637,0.0002763453,0.001750179,0.0008286731,0.00007112,0.00001788102,0.0003509664],"genre_scores_gemma":[0.9905261,0.006943129,0.0001897185,0.00004903569,0.0003394908,0.0002757131,0.00002820374,0.00003854673,0.001610011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07474079,"threshold_uncertainty_score":0.5781029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028614065841257,"score_gpt":0.324249249533647,"score_spread":0.3039631088752345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}