{"id":"W2127729727","doi":"10.1128/aac.47.7.2082-2087.2003","title":"<i>Burkholderia pseudomallei</i> Class A β-Lactamase Mutations That Confer Selective Resistance against Ceftazidime or Clavulanic Acid Inhibition","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"","keywords":"Burkholderia pseudomallei; Melioidosis; Ceftazidime; Microbiology; Clavulanic acid; Biology; Burkholderia; Antibiotics; Bacteria; Genetics; Amoxicillin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001498937,0.0003217072,0.0004157907,0.000145856,0.0003451657,0.00009754158,0.00004766394,0.0002169366,0.0005214851],"category_scores_gemma":[0.00002902916,0.0002672776,0.0001473074,0.0003798973,0.0001543749,0.0001919163,0.00001404484,0.0002421341,0.00002725212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008510677,"about_ca_system_score_gemma":0.0001688814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002334974,"about_ca_topic_score_gemma":0.00006445748,"domain_scores_codex":[0.9985397,0.00007648494,0.0003184912,0.0004923922,0.0001703817,0.0004025432],"domain_scores_gemma":[0.9992095,0.0000311574,0.000146246,0.0002747159,0.0001536022,0.0001848263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001618973,0.001512007,0.01022728,0.0002647434,0.0006127352,0.0001661382,0.00141568,0.000004315551,0.7715915,0.0009279831,0.2086203,0.003038342],"study_design_scores_gemma":[0.01194114,0.0003720103,0.01395406,0.0003709167,0.0002248904,0.0002792293,0.0003577821,0.00003341587,0.5576395,0.0001282036,0.4140533,0.0006456127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852194,0.00007395758,0.0005396497,0.003323218,0.0002679069,0.0007696842,0.00004068585,0.0001225655,0.009643001],"genre_scores_gemma":[0.9770783,0.001839921,0.001217683,0.01635643,0.0001229348,0.00004741118,0.00009557371,0.00006584299,0.003175945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.213952,"threshold_uncertainty_score":0.9999779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223126923807761,"score_gpt":0.2613704381427949,"score_spread":0.2390577457620188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}