{"id":"W2127738863","doi":"10.1016/j.bcp.2011.10.009","title":"Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer","year":2011,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"Onyx Pharmaceuticals; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Koninklijke Nederlandse Akademie van Wetenschappen; Merck KGaA","keywords":"Bortezomib; Proteasome; Lung cancer; Proteasome inhibitor; Cancer research; Cancer; Medicine; Biology; Chemistry; Oncology; Cell biology; Immunology; Internal medicine; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003206215,0.0001971762,0.0002787736,0.000247899,0.0001792818,0.0004605001,0.0002423944,0.0002085444,0.0006971964],"category_scores_gemma":[0.000142499,0.0001573894,0.0001724359,0.0001725579,0.0002802786,0.0003886885,0.0001669426,0.0006466814,0.0001315162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006171083,"about_ca_system_score_gemma":0.0002326697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003003525,"about_ca_topic_score_gemma":0.0008484097,"domain_scores_codex":[0.9998733,0.00002994072,0.00001044143,0.00001205308,0.00003907263,0.00003510614],"domain_scores_gemma":[0.9999554,0.000007966033,0.00001247205,0.000007094677,0.000006817031,0.00001024596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009828461,0.0002159196,0.004210747,0.0002132456,0.00006611417,0.0007597495,0.00007756963,0.0009768712,0.9578382,0.00590213,0.0005095942,0.02824705],"study_design_scores_gemma":[0.0003587562,0.002633926,0.1133227,0.00003953444,0.000152449,0.008159085,0.0002386548,0.006395896,0.8487365,0.005646119,0.01427465,0.00004171656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697552,0.02250738,0.00260243,0.0009221642,0.00004860282,0.00003072119,0.0001869154,0.0001008985,0.003845674],"genre_scores_gemma":[0.9956443,0.003157681,0.0002662892,0.00005545729,0.00001638717,0.0000108524,0.00007814408,0.000003550419,0.0007673294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006971964,"threshold_uncertainty_score":0.004477382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507169547866152,"score_gpt":0.2578289572114701,"score_spread":0.2427572617328086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}