{"id":"W2127738863","doi":"10.1016/j.bcp.2011.10.009","title":"Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer","year":2011,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"Onyx Pharmaceuticals; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Koninklijke Nederlandse Akademie van Wetenschappen; Merck KGaA","keywords":"Bortezomib; Proteasome; Lung cancer; Proteasome inhibitor; Cancer research; Cancer; Medicine; Biology; Chemistry; Oncology; Cell biology; Immunology; Internal medicine; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851019,0.0001997268,0.0002534879,0.00007330086,0.00002790681,0.000003801063,0.0002301603,0.0002742458,0.0001348728],"category_scores_gemma":[0.00002198578,0.0002024624,0.00006249127,0.0001271894,0.0001642103,0.000003246532,0.0001351338,0.0001152132,0.000001739187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002587945,"about_ca_system_score_gemma":0.0001449924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004694216,"about_ca_topic_score_gemma":0.00001363647,"domain_scores_codex":[0.9987522,0.00008273021,0.0002993276,0.0004479022,0.00007860794,0.0003392475],"domain_scores_gemma":[0.9994532,0.00001655607,0.0001421171,0.0001894173,0.00007260792,0.0001260775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007291729,0.0001901079,0.001214884,0.0002461214,0.00002785557,0.000008865816,0.00008635065,6.608653e-7,0.9933029,0.00005916198,0.004010353,0.0001235008],"study_design_scores_gemma":[0.002036871,0.0001564223,0.001636299,0.0000366262,0.00004099455,0.000001402575,0.00001478229,0.00005012628,0.9950562,0.0002512484,0.0004955943,0.0002234486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931694,0.00414205,0.0007150201,0.0000872656,0.0001510929,0.000740687,0.00004297726,0.00001237489,0.0009391007],"genre_scores_gemma":[0.9948123,0.000175841,0.003874443,0.0005193241,0.00009993701,0.0003377864,0.00002703581,0.00002581641,0.00012748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003966209,"threshold_uncertainty_score":0.8256179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507169547866152,"score_gpt":0.2578289572114701,"score_spread":0.2427572617328086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}