{"id":"W2127749273","doi":"10.1177/1947601911408888","title":"Impaired MicroRNA Processing Facilitates Breast Cancer Cell Invasion by Upregulating Urokinase-Type Plasminogen Activator Expression","year":2011,"lang":"en","type":"article","venue":"Genes & Cancer","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Dicer; Drosha; microRNA; Gene knockdown; Urokinase receptor; Biology; Cancer research; Gene silencing; Cancer cell; Downregulation and upregulation; RNA interference; Cancer; Cell culture; Cell; Transfection; Small interfering RNA; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051977,0.0002201069,0.0002066899,0.0001401178,0.0000943858,0.0003150516,0.000111155,0.0001570771,0.0008880851],"category_scores_gemma":[0.0001096369,0.0001397533,0.0002336345,0.00008801885,0.0001247623,0.0001165641,0.0001604615,0.0004596751,0.0003431845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611446,"about_ca_system_score_gemma":0.0001443752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002290049,"about_ca_topic_score_gemma":0.0002675578,"domain_scores_codex":[0.9998721,0.00002539165,0.00001560765,0.00002209827,0.00003475864,0.00003003769],"domain_scores_gemma":[0.9999058,0.00002327287,0.00002826567,0.00001467576,0.00001002959,0.00001800315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003438829,0.00001227628,0.0001517039,0.00001355654,0.000002264382,0.00002841942,0.000006690874,0.00002766259,0.9991997,0.0000285588,0.00001670636,0.000478033],"study_design_scores_gemma":[0.000007177183,0.0001287917,0.003264677,0.000001851728,0.000008517876,0.0001996546,0.00001439965,0.0009106306,0.9942309,0.00002159512,0.001208976,0.000002755821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965935,0.0007565687,0.001567297,0.00005392768,0.00001685698,0.00001155057,0.0001340565,0.00005338456,0.0008127657],"genre_scores_gemma":[0.9962447,0.0004890438,0.001723614,0.00003180186,0.000005996097,0.00002034486,0.0003019375,0.000007740804,0.001174742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008880851,"threshold_uncertainty_score":0.002970934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846213822006402,"score_gpt":0.2468398261925177,"score_spread":0.2283776879724537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}