{"id":"W2127766722","doi":"10.1158/1541-7786.mcr-06-0095","title":"Baseline Gene Expression Predicts Sensitivity to Gefitinib in Non–Small Cell Lung Cancer Cell Lines","year":2006,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Gefitinib; Lung cancer; Cancer research; Epidermal growth factor receptor; Microarray; Biology; Gene expression profiling; Gene expression; Gene; Microarray analysis techniques; Cancer; Oncology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006741912,0.0002405769,0.0003388889,0.0002936625,0.0001455945,0.00004598378,0.0001157231,0.0001361175,0.0002537459],"category_scores_gemma":[0.00004821358,0.0002112329,0.00009619988,0.0006953061,0.0000550512,0.0000743819,0.0001459572,0.0003946625,0.0000224396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001017804,"about_ca_system_score_gemma":0.0008515044,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04094923,"about_ca_topic_score_gemma":0.008015593,"domain_scores_codex":[0.9971796,0.0002562854,0.0003312219,0.0006703575,0.000792495,0.0007700104],"domain_scores_gemma":[0.9985431,0.0001054743,0.00005359065,0.0004826377,0.0005049265,0.000310229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002716537,0.0005740009,0.02626738,0.0003447059,0.00003245357,0.001082284,0.0004098929,0.005410364,0.9547139,0.000005823775,0.00869999,0.002187496],"study_design_scores_gemma":[0.003245188,0.0001739228,0.01858263,0.0005421003,0.0001063813,0.000006852117,0.0001062786,0.003604887,0.9696297,0.00001531822,0.003751036,0.0002356886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808189,0.007136744,0.002749666,0.002113817,0.0001571975,0.001913611,0.0002075374,0.00004892397,0.004853637],"genre_scores_gemma":[0.9895782,0.0005448735,0.002738294,0.0005468139,0.0004845189,0.001211809,0.0001524655,0.00007433911,0.004668691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03293363,"threshold_uncertainty_score":0.9654372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02592032282648933,"score_gpt":0.3855937390332659,"score_spread":0.3596734162067766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}