{"id":"W2127767332","doi":"10.1186/1897-4287-10-3","title":"The R337H mutation in TP53 and breast cancer in Brazil","year":2012,"lang":"en","type":"article","venue":"Hereditary Cancer in Clinical Practice","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital","funders":"","keywords":"Medicine; Breast cancer; Germline mutation; Li–Fraumeni syndrome; Penetrance; Oncology; Mutation; Cancer; Population; Incidence (geometry); Internal medicine; Family history; Mutation frequency; Genetics; Environmental health; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002943659,0.0001931562,0.0003922771,0.000112799,0.0000575983,0.00002321235,0.000116263,0.0002970877,0.0002266963],"category_scores_gemma":[0.002741422,0.0001583349,0.0000708021,0.000557134,0.0002037157,0.0006655112,0.00008056787,0.001574587,0.00002603799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005770265,"about_ca_system_score_gemma":0.0006148172,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.008430273,"about_ca_topic_score_gemma":0.02150422,"domain_scores_codex":[0.9971516,0.0005110176,0.0009902661,0.0004147933,0.0004052397,0.0005271579],"domain_scores_gemma":[0.996108,0.002931652,0.0002684363,0.000352347,0.0001165294,0.0002230405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005307381,0.001221747,0.4798293,0.000149755,0.0001654885,0.0009819316,0.001162235,0.0006500074,0.0001977145,0.0002297794,0.008765052,0.5013396],"study_design_scores_gemma":[0.004594093,0.0001490257,0.9473453,0.0004700121,0.0001320576,0.0004524762,0.000953646,0.0008884009,0.00003446889,0.0001168963,0.04464285,0.0002208442],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8702587,0.0554915,0.00002667581,0.06168994,0.004495897,0.001230312,0.0001025175,0.00005197218,0.006652504],"genre_scores_gemma":[0.9802679,0.01379134,0.0002301614,0.003880506,0.001478522,0.0001940726,0.000008247341,0.00004148318,0.0001077564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5011188,"threshold_uncertainty_score":0.9981727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04241918272541022,"score_gpt":0.4333913986520805,"score_spread":0.3909722159266703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}