{"id":"W2127781140","doi":"10.1002/anie.201309436","title":"Discovery of Inhibitors of Shiga Toxin Type 2 by On‐Plate Generation and Screening of a Focused Compound Library","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Microtiter plate; Toxin; Combinatorial chemistry; Function (biology); Plate reader; Masking (illustration); Chemistry; Ligand (biochemistry); Computational biology; Nanotechnology; Biochemistry; Materials science; Chromatography; Biology; Fluorescence; Optics; Physics; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004193793,0.001183687,0.0009857621,0.0008333693,0.0002011247,0.0006070377,0.0008634079,0.0005071684,0.001949425],"category_scores_gemma":[0.0003059615,0.0004450305,0.0004708103,0.00053483,0.0002276134,0.0002837927,0.0004012901,0.0006468848,0.0008618076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004298476,"about_ca_system_score_gemma":0.0005652471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009743269,"about_ca_topic_score_gemma":0.003435873,"domain_scores_codex":[0.9996951,0.00005480321,0.00001397861,0.00004860289,0.000133279,0.00005441221],"domain_scores_gemma":[0.9998568,0.0000333752,0.00001939338,0.00001619046,0.00004333066,0.00003074157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000178186,0.00017921,0.000155516,0.0000795367,0.00002713996,0.00007506242,0.00002189225,0.001110534,0.9857479,0.0001349417,0.0002283053,0.01206184],"study_design_scores_gemma":[0.0001111481,0.002067928,0.0008053114,0.00001064971,0.00005493252,0.0001887275,0.00002541349,0.002839168,0.9901897,0.00004054095,0.003646621,0.00001984183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9177107,0.006452496,0.06205578,0.0003035837,0.0001028848,0.001428601,0.003263708,0.0009552991,0.007727009],"genre_scores_gemma":[0.900373,0.008602696,0.06843432,0.0002858273,0.00004500527,0.000981672,0.00569604,0.0001565389,0.01542489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949425,"threshold_uncertainty_score":0.006521463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566201483786547,"score_gpt":0.2574571385897186,"score_spread":0.2417951237518532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}