{"id":"W2127834887","doi":"10.1056/nejmoa1109017","title":"Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis","year":2012,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":929,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Medicine; Psoriasis Area and Severity Index; Placebo; Psoriasis; Internal medicine; Randomization; Gastroenterology; Body surface area; Clinical endpoint; Dose-ranging study; Interleukin 17; Randomized controlled trial; Immunology; Cytokine; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001081723,0.0002223023,0.0006031868,0.0002091241,0.000117238,0.000007512256,0.0002367962,0.0001730716,0.001367932],"category_scores_gemma":[0.000234435,0.0001273207,0.0001530511,0.0001047368,0.0001046814,0.0002551546,0.00001722674,0.0002042482,0.00005148388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004766832,"about_ca_system_score_gemma":0.00007963355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005008868,"about_ca_topic_score_gemma":0.00001206155,"domain_scores_codex":[0.9986097,0.0001974023,0.0005371073,0.0001433958,0.00008485146,0.000427492],"domain_scores_gemma":[0.9987457,0.0003458544,0.0003741705,0.0001974787,0.0001614747,0.0001752866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002262861,0.0003994878,0.0290453,0.00002431798,0.0008387223,0.00001210909,0.003116864,0.0000023017,0.3551346,0.0002508022,0.06660109,0.5423115],"study_design_scores_gemma":[0.07709754,0.004179304,0.02650673,0.0002054049,0.0009161087,0.001319076,0.0006025255,0.000001312953,0.03834253,0.0002042981,0.8503525,0.0002726132],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755125,0.01257003,0.00120983,0.00181585,0.008065401,0.0002000778,0.00002970826,0.00002627698,0.0005703317],"genre_scores_gemma":[0.9871441,0.0006774374,0.0007836824,0.0002874018,0.007783644,0.000003161885,0.0001537695,0.00002588958,0.00314088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7837515,"threshold_uncertainty_score":0.999545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02568001421573626,"score_gpt":0.2981064434153324,"score_spread":0.2724264291995962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}