{"id":"W2127834887","doi":"10.1056/nejmoa1109017","title":"Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis","year":2012,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":929,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Medicine; Psoriasis Area and Severity Index; Placebo; Psoriasis; Internal medicine; Randomization; Gastroenterology; Body surface area; Clinical endpoint; Dose-ranging study; Interleukin 17; Randomized controlled trial; Immunology; Cytokine; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001322884,0.0005834039,0.0009481907,0.0004163636,0.0002259926,0.0004374201,0.0005479016,0.0007029896,0.003487827],"category_scores_gemma":[0.0005792332,0.0003561635,0.0006269777,0.0002200578,0.0003884164,0.0003120075,0.0001602069,0.001446459,0.0008168295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704454,"about_ca_system_score_gemma":0.0005503668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002037127,"about_ca_topic_score_gemma":0.0009478178,"domain_scores_codex":[0.9996009,0.000180382,0.00002950236,0.00005390549,0.00006819136,0.00006701869],"domain_scores_gemma":[0.9996222,0.00009237792,0.0001147923,0.00002080118,0.00002661611,0.0001232867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.3838546,0.05257718,0.01173146,0.003726545,0.002094635,0.000703553,0.0001584262,0.002105322,0.1388901,0.0005622715,0.00756511,0.3960308],"study_design_scores_gemma":[0.7505215,0.2126746,0.01725578,0.000131772,0.0008486406,0.001331195,0.00002922705,0.001062294,0.007213163,0.0001583583,0.008733611,0.00003980853],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711308,0.01894113,0.002027012,0.0008956032,0.0004369392,0.002961586,0.0005603232,0.0001874275,0.002859277],"genre_scores_gemma":[0.9816713,0.008008958,0.003962794,0.001802903,0.0005307228,0.001590432,0.0007019519,0.0000187508,0.001712291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003487827,"threshold_uncertainty_score":0.01166797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02568001421573626,"score_gpt":0.2981064434153324,"score_spread":0.2724264291995962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}