{"id":"W2127842501","doi":"10.1091/mbc.e13-07-0423","title":"Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1","year":2014,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Biology; Repressor; Protein arginine methyltransferase 5; Methyltransferase; Psychological repression; Protein methylation; Cell biology; Methylation; Transcription factor; Protein subunit; Transcription (linguistics); Arginine; Hypoxia-Inducible Factor 1; Activator (genetics); Transcriptional regulation; Molecular biology; Gene expression; Biochemistry; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003076155,0.000173358,0.0002016504,0.00003200138,0.00007845464,0.000003933787,0.000420532,0.0002859354,0.0000327148],"category_scores_gemma":[0.00006625422,0.0001104477,0.0002301467,0.0001317826,0.0002993058,0.000002630527,0.00007096931,0.0001507756,0.000001785803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001098448,"about_ca_system_score_gemma":0.00005811612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004353363,"about_ca_topic_score_gemma":0.000007145669,"domain_scores_codex":[0.998578,0.0004025604,0.0003213635,0.0003565609,0.0001456197,0.0001959543],"domain_scores_gemma":[0.9989369,0.00001989117,0.0001943945,0.0007186544,0.00009096059,0.00003920327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009481687,0.00006768957,0.0001462409,0.00002564049,0.00005610907,7.772158e-8,0.0000302899,0.0004996699,0.9970398,0.0002062669,0.0003453024,0.001488077],"study_design_scores_gemma":[0.0006413003,0.0002648244,0.0006097698,0.00002140063,0.0000380329,0.000003504996,0.00000752434,0.00009204278,0.985998,0.0005351453,0.0116661,0.0001223323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698746,0.00264346,0.02548759,0.0008297279,0.0001617634,0.0004648556,0.00007071123,0.000006970549,0.0004603282],"genre_scores_gemma":[0.9986503,0.00003391105,0.000381178,0.00009616297,0.00005507939,0.00003083824,0.00011637,0.00002213499,0.0006139976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02877573,"threshold_uncertainty_score":0.4503925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006271304513499627,"score_gpt":0.2294957939352806,"score_spread":0.2232244894217809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}