{"id":"W2127842501","doi":"10.1091/mbc.e13-07-0423","title":"Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1","year":2014,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Biology; Repressor; Protein arginine methyltransferase 5; Methyltransferase; Psychological repression; Protein methylation; Cell biology; Methylation; Transcription factor; Protein subunit; Transcription (linguistics); Arginine; Hypoxia-Inducible Factor 1; Activator (genetics); Transcriptional regulation; Molecular biology; Gene expression; Biochemistry; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249219,0.0002541254,0.0002027104,0.0001572112,0.0002179507,0.0003135312,0.0002109969,0.0001959639,0.0007915029],"category_scores_gemma":[0.0001619133,0.00008962514,0.0001438236,0.0001483821,0.0002149318,0.000168673,0.0002378239,0.0004293515,0.0004326948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003516169,"about_ca_system_score_gemma":0.0002125146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000348324,"about_ca_topic_score_gemma":0.0004373309,"domain_scores_codex":[0.9998877,0.00002042769,0.000005934856,0.00003289543,0.00003114423,0.00002194177],"domain_scores_gemma":[0.9999231,0.00001201602,0.00002660181,0.000007981966,0.00001201768,0.00001826059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004946845,0.00001414022,0.0002744315,0.0000396356,0.000002885751,0.00006536378,0.00001443598,0.00008065593,0.9962549,0.0004023215,0.0001396916,0.002661971],"study_design_scores_gemma":[0.00002023238,0.0001678557,0.008569225,0.00001005037,0.0000118843,0.0005010499,0.0000286323,0.002375873,0.9732501,0.0002496602,0.01480844,0.000007064581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576604,0.01874729,0.01621518,0.0006352534,0.0001490465,0.00005230203,0.000513742,0.0003412736,0.005685427],"genre_scores_gemma":[0.9878176,0.004312838,0.00364563,0.00009768957,0.00003317393,0.00002851705,0.0005614911,0.00002190243,0.003481147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007915029,"threshold_uncertainty_score":0.002647817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006271304513499627,"score_gpt":0.2294957939352806,"score_spread":0.2232244894217809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}