{"id":"W2127899638","doi":"10.1038/emboj.2012.261","title":"Arginine methylation next to the PY‐NLS modulates Transportin binding and nuclear import of FUS","year":2012,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":325,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"NIHR Oxford Biomedical Research Centre; Parkinson's UK; Hans und Ilse Breuer-Stiftung; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Österreichischen Akademie der Wissenschaften; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Robert Bosch Stiftung; Deutsche Forschungsgemeinschaft; Elitenetzwerk Bayern; Canadian Institutes of Health Research; National Science Foundation","keywords":"NLS; Biology; Arginine; Nuclear localization sequence; Neurodegeneration; Nuclear transport; Methylation; Cell biology; Molecular biology; Cell nucleus; Biochemistry; Amino acid; Pathology; Gene; Nucleus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000634878,0.00007603229,0.00009111234,0.00003790398,0.0001320632,0.00001962485,0.00010616,0.00005564055,0.00003173421],"category_scores_gemma":[0.00002979302,0.00004629162,0.00005696771,0.00009285095,0.0000360072,0.000009601688,0.00002660286,0.0001071716,0.000002178924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001204061,"about_ca_system_score_gemma":0.00002411597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008163761,"about_ca_topic_score_gemma":0.000005975287,"domain_scores_codex":[0.9993922,0.00005227845,0.0002225415,0.00007590067,0.0001051318,0.0001520243],"domain_scores_gemma":[0.9995781,0.00001136024,0.0001547033,0.0001526586,0.00004565099,0.00005756679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001019643,0.0000167732,0.001837754,0.000006050113,0.00008708006,2.347816e-7,0.00084226,0.002877344,0.9780737,0.00009845215,0.0009588248,0.01509952],"study_design_scores_gemma":[0.001401234,0.0004571851,0.1396281,0.0001156121,0.0003582088,0.0004976177,0.00138752,0.002350783,0.7558407,0.0004720259,0.09705855,0.0004323891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954513,0.00208246,0.0006347502,0.001307263,0.0002123006,0.000114858,0.00000399972,0.000003030518,0.000190026],"genre_scores_gemma":[0.9987231,0.0003150509,0.0002422761,0.00007629207,0.0004378243,0.000001632419,0.000007710705,0.000010894,0.0001851469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.222233,"threshold_uncertainty_score":0.1887718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372566436330212,"score_gpt":0.2517679875957876,"score_spread":0.2380423232324855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}