{"id":"W2127899638","doi":"10.1038/emboj.2012.261","title":"Arginine methylation next to the PY‐NLS modulates Transportin binding and nuclear import of FUS","year":2012,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":325,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"NIHR Oxford Biomedical Research Centre; Parkinson's UK; Hans und Ilse Breuer-Stiftung; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Österreichischen Akademie der Wissenschaften; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Robert Bosch Stiftung; Deutsche Forschungsgemeinschaft; Elitenetzwerk Bayern; Canadian Institutes of Health Research; National Science Foundation","keywords":"NLS; Biology; Arginine; Nuclear localization sequence; Neurodegeneration; Nuclear transport; Methylation; Cell biology; Molecular biology; Cell nucleus; Biochemistry; Amino acid; Pathology; Gene; Nucleus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001927864,0.0001722907,0.0002239086,0.00007102604,0.0002300573,0.0003230217,0.0003380298,0.0002950035,0.003234775],"category_scores_gemma":[0.0003903619,0.0001684266,0.0002039348,0.0000815579,0.000414007,0.0004354857,0.0003413006,0.0004839964,0.0005437419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00045659,"about_ca_system_score_gemma":0.000195565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001076039,"about_ca_topic_score_gemma":0.001645382,"domain_scores_codex":[0.9998691,0.00002417699,0.00001006638,0.00003185762,0.00002197711,0.00004285349],"domain_scores_gemma":[0.9998432,0.00003446151,0.00004603866,0.00001948182,0.00001342403,0.00004326813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004981089,0.00001164325,0.0001520702,0.00001375615,0.000003752801,0.00004905213,0.00001571682,0.00006904713,0.9983255,0.0001828073,0.0000231994,0.0006553062],"study_design_scores_gemma":[0.00004046773,0.0001304815,0.003638241,0.000002621322,0.0000103962,0.0001503435,0.00004347445,0.001473631,0.993369,0.000124445,0.001008297,0.000008514575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969556,0.0003633478,0.00137647,0.0001099174,0.00002292186,0.000007918449,0.00006502314,0.00003835056,0.00106047],"genre_scores_gemma":[0.9986456,0.00007193255,0.0003683225,0.00002433274,0.000003919094,0.000003193685,0.00004843464,0.00001418616,0.0008199598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003234775,"threshold_uncertainty_score":0.0108214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372566436330212,"score_gpt":0.2517679875957876,"score_spread":0.2380423232324855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}