{"id":"W2127901736","doi":"10.1093/infdis/jit465","title":"Protection Against Lethal Marburg Virus Infection Mediated by Lipid Encapsulated Small Interfering RNA","year":2013,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; University of Texas Medical Branch","keywords":"Small interfering RNA; Marburg virus; In vivo; In vitro; Virology; RNA interference; Messenger RNA; Biology; Virus; RNA; Medicine; Biochemistry; Gene; Ebola virus; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004735108,0.000238665,0.0003761087,0.0004105799,0.000301688,0.0001109501,0.0001151838,0.0001315826,0.0005311292],"category_scores_gemma":[0.000578086,0.0001527739,0.0002665386,0.0005871004,0.0001450826,0.0003966701,0.00006967301,0.0007962227,0.0001480345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200299,"about_ca_system_score_gemma":0.000155819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002420775,"about_ca_topic_score_gemma":0.00009678019,"domain_scores_codex":[0.9981571,0.0003186531,0.0006121173,0.0001510703,0.00040452,0.0003564798],"domain_scores_gemma":[0.9981596,0.0001468931,0.0003916961,0.0002248389,0.0007311351,0.0003457618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006842128,0.001175199,0.03277351,0.0001582822,0.000648196,0.00003911237,0.0002276553,0.0007270442,0.9071247,0.000003860864,0.008648331,0.0477899],"study_design_scores_gemma":[0.02011205,0.01849948,0.5396463,0.002419043,0.002750522,0.008321971,0.0007940853,0.02003936,0.3685893,0.0008865262,0.01599322,0.001948225],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937586,0.0004835739,0.002442054,0.0005452396,0.0005218381,0.000732584,0.00001090471,0.0001270489,0.001378141],"genre_scores_gemma":[0.9973765,0.001409888,0.000007505567,0.0002535949,0.0005931791,0.0000450884,0.00001425875,0.00004093219,0.0002590532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5385354,"threshold_uncertainty_score":0.6229938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802249567540662,"score_gpt":0.264795676074199,"score_spread":0.2467731803987924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}