{"id":"W2127920700","doi":"10.1128/jb.187.19.6622-6630.2005","title":"Cpx Signal Transduction Is Influenced by a Conserved N-Terminal Domain in the Novel Inhibitor CpxP and the Periplasmic Protease DegP","year":2005,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Periplasmic space; Biology; Response regulator; Protease; Signal transduction; Mutant; Cell biology; Conserved sequence; Mutation; Peptide sequence; Cell envelope; Biochemistry; Genetics; Escherichia coli; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001530503,0.000346785,0.000167834,0.00008289642,0.0001237095,0.0003168239,0.0002415536,0.0001849448,0.0003406784],"category_scores_gemma":[0.0001707777,0.0001399368,0.0001396153,0.00005869769,0.0002807506,0.0002565313,0.0002245069,0.0004368482,0.0001765949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003882852,"about_ca_system_score_gemma":0.0001524757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003517533,"about_ca_topic_score_gemma":0.0002677119,"domain_scores_codex":[0.9998542,0.00002648319,0.00001249921,0.00002927348,0.00005182833,0.00002562148],"domain_scores_gemma":[0.9998643,0.00003117687,0.00004716461,0.00001414036,0.00001439154,0.00002874999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007312699,0.000009679185,0.0002060952,0.00000859068,0.000001709017,0.00005040781,0.000003888973,0.00005223494,0.9989949,0.0000648488,0.000006349375,0.0005282248],"study_design_scores_gemma":[0.000009224962,0.0000861531,0.004861288,0.000002368484,0.000006583685,0.0005502321,0.000009966641,0.001757238,0.9919606,0.0000388839,0.0007146084,0.000002894167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966174,0.0003833547,0.002636133,0.00003719922,0.00000453296,0.000006800277,0.00004097687,0.00001958512,0.0002541665],"genre_scores_gemma":[0.9973776,0.0002227192,0.001655705,0.00002439661,0.000004192845,0.000008298485,0.0001357213,0.000009383563,0.0005620249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003882852,"threshold_uncertainty_score":0.002817154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006349856143970825,"score_gpt":0.2203623816985376,"score_spread":0.2140125255545668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}