{"id":"W2127920700","doi":"10.1128/jb.187.19.6622-6630.2005","title":"Cpx Signal Transduction Is Influenced by a Conserved N-Terminal Domain in the Novel Inhibitor CpxP and the Periplasmic Protease DegP","year":2005,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Periplasmic space; Biology; Response regulator; Protease; Signal transduction; Mutant; Cell biology; Conserved sequence; Mutation; Peptide sequence; Cell envelope; Biochemistry; Genetics; Escherichia coli; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006719525,0.0001612764,0.0002671669,0.000060712,0.00007960466,0.00003665865,0.0002969328,0.0003066399,0.00003405597],"category_scores_gemma":[0.00004316769,0.00009205899,0.0001028216,0.00007371059,0.0005441901,0.000009453129,0.00005173622,0.0003261272,0.000001300397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001522213,"about_ca_system_score_gemma":0.00009638762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001613003,"about_ca_topic_score_gemma":0.00003598155,"domain_scores_codex":[0.9987723,0.0002351881,0.0004902887,0.000192633,0.00008825873,0.000221328],"domain_scores_gemma":[0.9993775,0.00003242891,0.0002945615,0.0001744064,0.00007395011,0.00004713193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001372138,0.00008180586,0.0005145597,0.000007180996,0.00003543699,0.000006544935,0.0003316883,0.000004590763,0.9952435,0.00003154963,0.0003524979,0.002018428],"study_design_scores_gemma":[0.01202759,0.003137339,0.01396027,0.00005483246,0.00009594039,0.006944038,0.0006472953,0.00009668961,0.8046459,0.0003589075,0.1576141,0.0004170634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897141,0.0005691315,0.0001857538,0.009095713,0.0001329574,0.0002633951,0.00002290881,0.000002149142,0.00001389926],"genre_scores_gemma":[0.9968657,0.0003028348,0.0007516399,0.001589304,0.0004317893,0.0000176112,0.000009142765,0.000009903347,0.00002205841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1905977,"threshold_uncertainty_score":0.3754056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006349856143970825,"score_gpt":0.2203623816985376,"score_spread":0.2140125255545668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}